Clinical Study

Efficacy of Scutellaria baicalensis for the Treatment of Hand, Foot, and Mouth Disease Associated with Encephalitis in Patients Infected with EV71: A Multicenter, Retrospective Analysis

Table 4

Comparison of efficiency and invalid cases in the Scutellaria baicalensis group.

VariableEfficiency ()Invalid ()/-test ( value)

Sex
 Male165 (53.9)58 (54.7)0.0201 (0.8874)
 Female141 (46.1)48 (45.3)
Age (months)6.4962 (0.0000)
Fever >39°C over 3 days26 (8.5)92 (86.8)236.1409 (0.0000)
NS involvement

 Poor spirit207 (67.6)76 (71.7)0.6007 (0.4383)
 Headache and vomiting196 (64.1)72 (67.9)0.5192 (0.4712)
 Limb jitters12 (3.9)46 (43.4)101.4215 (0.0000)
 Nystagmus0 (0.0)16 (15.1)— (0.0000)
 Ataxia1 (0.3)8 (7.5)15.9781 (0.0001)
 Acute flaccid paralysis6 (1.96)17 (16.0)29.5981 (0.0000)
 Convulsion45 (14.7)22 (20.8)2.1153 (0.1458)
 Irritation sign152 (49.7)61 (57.5)1.9547 (0.1621)
FBG level (mmol/L)7.3916 (0.0000)
PWBC count (×109/L)10.0999 (0.0000)
CSF-WBC count (×106/L)1.5829 (0.1142)
EEG abnormality194 (63.4)68 (64.2)0.2566 (0.6125)
MRI abnormality80 (26.1)32 (30.2)0.6507 (0.4199)

A fever of >39°C over 3 days referred to 39°C at least once a day and persisted for more than 3 days, with no downward trend. Nystagmus data were compared using Fisher’s exact test. NS: nervous system; FBG: fasting blood glucose; PWBC: peripheral white blood cells; CSF-WBC: cerebrospinal fluid-white blood cells; EEG: electroencephalograph; MRI: magnetic resonance imaging.