Clinical Study
Ultrasound for Appendicitis: Performance and Integration with Clinical Parameters
Table 4
Integration of ultrasound with pediatric appendicitis score (PAS) and C-reactive protein (CRP) in the diagnosis of pediatric appendicitis.
| | | US positive
N (% appendicitis) | US negative
N (% appendicitis) | Patients
(N) |
| | PAS | | | | | 0–3 | 7 (0%) | 116 (0%) | 123 | | 4–6 | 59 (93%) | 143 (7%) | 202 | | 7–10 | 40 (100%) | 37 (31%) | 77 |
| | CRP (mg/L) | | | | | <15 | 36 (89%) | 191 (5%) | 227 | | 15 | 74 (91%) | 122 (8%) | 196 |
| | PAS 5 + CRP < 5 | 9 (50%) | 118 (3%) | 127 |
| | Diagnostic performance% (95% CI) |
| | Negative US + CRP < 15 | Sens. 92 (85–96), spec. 60 (54–65), PPV 47 (40–54), NPV 95 (91–97), LR+ 2.26 (1.95–2.60), LR− 0.14 (0.08–0.26) |
| | Negative US + PAS 5 + CRP < 5 | Sens. 98 (92–99), spec. 41 (36–48), PPV 39 (34–46), NPV 98 (92–99), LR+ 1.66 (1.45–2.01), LR− 0.05 (0.03–0.15) |
|
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US: ultrasound; CRP: C-reactive protein; PAS: pediatric appendicitis score; PPV: positive predictive value; NPV: negative predictive value; CI: confidence interval; LR: likelihood ratio; patients lacking PAS () or CRP () were not included.
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