Oxidative Stress and Liver Morphology in Experimental Cyclosporine A-Induced Hepatotoxicity

Table 2

Hepatic levels of GSH, GSSG, LPH, /NADPH, /NADH, ADP/ATP, and caspase 3 in all experimental groups.

	NaCl (A)	CsA (B)	Olive oil (C)
GSH [nmol/g]	6,65 0,64	3,3 0,48	6,37 0,74
GSSG [nmol/g]	0,38 0,07	1,33 0,23	0,4 0,09
MDA+4HAE [nmol/g]	3,13 0,94	12,68 1,26	3,41 0,56
/NADH	5,83 0,81	1,78 0,55	5,54 1,16
/NADPH	0,72 0,14	3,48 0,49	0,74 0,14
ADP/ATP	0,8 0,24	4,95 0,64	0,8 0,24
Caspase 3 [%]	99,93 18,94	232,22 21,44	103,13 18,94

Values are mean ± SEM. versus B and B versus C and p < 0,05.