Research Article
Lack of Association between Genetic Polymorphisms of JAK-STAT Signaling Pathway Genes and Acute Anterior Uveitis in Han Chinese
Table 5
Allele and genotype frequencies of SNPs in patients with AAU versus control subjects stratified by AS and HLA-B27 status.
| | Gene | SNP | Allele and genotype | AAU+AS+
HLA-B27 | AAU+AS−
HLA-B27 | Control | (AS+) | Pc (AS+) | OR (95% CI) | (AS-) | Pc (AS−) | OR (95% CI) |
| | JAK1 | rs310241 | C | 205 (31.6%) | 119 (29.9%) | 392 (27.5%) | 0.05 | NS | 1.22 (1.00–1.49) | 0.32 | NS | 1.13 (0.88–1.45) | | CC | 30 (9.3%) | 11 (5.5%) | 45 (6.3%) | 0.09 | NS | 1.52 (0.94–2.45) | 0.70 | NS | 0.87 (0.44–1.72) | | CT | 145 (44.7%) | 97 (48.7%) | 302 (42.4%) | 0.47 | NS | 1.10 (0.85–1.44) | 0.10 | NS | 1.31 (0.95–1.79) | | TT | 149 (46.0%) | 90 (45.7%) | 366 (51.3%) | 0.11 | NS | 0.81 (0.62–1.05) | 0.14 | NS | 0.79 (0.58–1.08) | | rs2780815 | G | 543 (84.3%) | 335 (89.6%) | 1250 (87.5%) | 0.05 | NS | 0.77 (0.59–1.00) | 0.28 | NS | 1.22 (0.85–1.77) | | GG | 230 (71.4%) | 151 (80.7%) | 548 (76.7%) | 0.07 | NS | 0.76 (0.56–1.02) | 0.24 | NS | 1.27 (0.85–1.90) | | GT | 83 (25.8%) | 33 (17.6%) | 154 (21.6%) | 0.14 | NS | 1.26 (0.93–1.72) | 0.23 | NS | 0.78 (0.51–1.18) | | TT | 9 (2.8%) | 3 (1.7%) | 12 (1.7%) | 0.24 | NS | 1.68 (0.70–4.03) | 0.94 | NS | 0.95 (0.27–3.42) |
| | JAK2 | rs10758669 | A | 449 (66.2%) | 256 (65.3%) | 980 (69.0%) | 0.20 | NS | 0.88 (0.72–1.70) | 0.16 | NS | 0.85 (0.67–1.07) | | AA | 139 (41.0%) | 81 (41.3%) | 346 (48.7%) | 0.02 | NS | 0.73 (0.56–0.95) | 0.07 | NS | 0.74 (0.54–1.02) | | AC | 171 (50.4%) | 94 (48.0%) | 288 (40.6%) | 2.56 × 10−3 | 0.084 | 1.49 (1.15–1.94) | 0.06 | NS | 1.35 (0.98–1.86) | | CC | 29 (8.6%) | 21 (10.7%) | 76 (10.7%) | 0.28 | NS | 0.78 (0.50–1.22) | 1.00 | NS | 1.00 (0.60–1.67) | | rs10975003 | C | 165 (25.7%) | 86 (22.5%) | 272 (21.2%) | 0.03 | NS | 1.29 (1.03–1.61) | 0.57 | NS | 1.08 (0.82–1.43) | | CC | 18 (5.6%) | 8 (4.2%) | 28 (4.4%) | 0.39 | NS | 1.31 (0.71–2.40) | 0.92 | NS | 0.96 (0.43–2.14) | | CT | 129 (40.2%) | 70 (36.6%) | 216 (33.5%) | 0.04 | NS | 1.33 (1.01–1.75) | 0.44 | NS | 1.14 (0.82–1.60) | | TT | 174 (54.2%) | 113 (59.2%) | 399 (62.1%) | 0.01 | NS | 0.72 (0.55–0.95) | 0.47 | NS | 0.89 (0.64–1.23) |
| | STAT1 | rs1547550 | C | 608 (88.1%) | 329 (85.7%) | 1254 (87.8%) | 0.84 | NS | 1.03 (0.78–1.36) | 0.26 | NS | 0.83 (0.60–1.15) | | CC | 264 (76.5%) | 143 (74.5%) | 555 (77.7%) | 0.66 | NS | 0.93 (0.69–1.27) | 0.34 | NS | 0.84 (0.58–1.21) | | CG | 80 (23.2%) | 43 (22.4%) | 144 (20.2%) | 0.26 | NS | 1.20 (0.88–1.63) | 0.50 | NS | 1.14 (0.78–1.68) | | GG | 1 (0.3%) | 6 (3.1%) | 15 (2.1%) | 0.02 | NS | 0.14 (0.02–103) | 0.40 | NS | 1.50 (0.58–3.93) | | rs2066802 | C | 130 (20.7%) | 60 (16.8%) | 288 (20.7%) | 0.99 | NS | 1.00 (0.79–1.26) | 0.09 | NS | 0.77 (0.57–1.05) | | CC | 11 (3.5%) | 4 (2.2%) | 27 (3.9%) | 0.77 | NS | 0.90 (0.44–1.83) | 0.29 | NS | 0.57 (0.20–1.64) | | CT | 108 (34.4%) | 52 (29.1%) | 234 (33.7%) | 0.82 | NS | 1.03 (0.78–1.37) | 0.24 | NS | 0.81 (0.56–1.16) | | TT | 195 (62.1%) | 123 (68.7%) | 434 (62.4%) | 0.92 | NS | 0.99 (0.75–1.30) | 0.12 | NS | 1.32 (0.93–1.88) | | rs6718902 | C | 368 (57.7%) | 216 (54.5%) | 778 (54.5%) | 0.18 | NS | 1.14 (0.94–1.38) | 0.98 | NS | 1.00 (0.80–1.25) | | CC | 103 (32.3%) | 60 (30.3%) | 209 (29.3%) | 0.33 | NS | 1.15 (0.87–1.53) | 0.78 | NS | 1.05 (0.75–1.48) | | CT | 162 (50.8%) | 96 (48.5%) | 360 (50.4%) | 0.91 | NS | 1.02 (0.78–1.32) | 0.63 | NS | 0.93 (0.68–1.27) | | TT | 54 (16.9%) | 42 (21.2%) | 145 (20.3%) | 0.20 | NS | 0.80 (0.57–1.13) | 0.78 | NS | 1.06 (0.72–1.56) | | rs10199181 | A | 170 (26.9%) | 100 (27.8%) | 397 (27.8%) | 0.67 | NS | 0.96 (0.77–1.18) | 0.99 | NS | 1.00 (0.77–1.29) | | AA | 25 (7.9%) | 18 (10.0%) | 55 (7.7%) | 0.91 | NS | 1.03 (0.63–1.68) | 0.32 | NS | 1.33 (0.76–2.33) | | AT | 120 (38.0%) | 64 (35.6%) | 287 (40.2%) | 0.50 | NS | 0.91 (0.69–1.20) | 0.26 | NS | 0.82 (0.58–1.15) | | TT | 171 (54.1%) | 98 (54.4%) | 372 (52.1%) | 0.55 | NS | 1.08 (0.83–1.41) | 0.57 | NS | 1.10 (0.79–1.53) |
| | IRF1 | rs2070721 | A | 221 (34.9%) | 135 (37.3%) | 487 (34.1%) | 0.73 | NS | 1.03 (0.85–1.26) | 0.25 | NS | 1.15 (0.90-1.46) | | AA | 37 (11.7%) | 24 (13.3%) | 74 (10.4%) | 0.53 | NS | 1.14 (0.75–1.74) | 0.26 | NS | 1.32 (0.81–2.16) | | AC | 147 (46.4%) | 87 (48.1%) | 339 (47.4%) | 0.74 | NS | 0.96 (0.73–1.25) | 0.89 | NS | 1.02 (0.74–1.42) | | CC | 133 (42.0%) | 70 (38.6%) | 301 (42.2%) | 0.95 | NS | 0.99 (0.76–1.30) | 0.40 | NS | 0.97 (0.62–1.21) |
| NOS2
| rs2297518 | A | 130 (19.0%) | 64 (16.5%) | 209 (16.2%) | 0.11 | NS | 1.22 (0.96–1.55) | 0.87 | NS | 1.03 (0.76–1.39) | | AA | 7 (2.0%) | 5 (2.6%) | 12 (1.9%) | 0.83 | NS | 1.11 (0.43–2.84) | 0.53 | NS | 1.40 (0.49–4.02) | | AG | 116 (33.9%) | 54 (27.8%) | 185 (28.6%) | 0.08 | NS | 1.28 (0.97–1.70) | 0.84 | NS | 0.96 (0.67–1.38) | | GG | 219 (64.1%) | 135 (69.6%) | 450 (69.5%) | 0.07 | NS | 0.78 (0.59–1.03) | 0.99 | NS | 1.00 (0.71–1.42) | rs4795067
| A | 512 (73.6%) | 295 (74.5%) | 1008 (76.1%) | 0.20 | NS | 0.87 (0.71–1.08) | 0.61 | NS | 0.92 (0.71–1.19) | | AA | 184 (52.9%) | 109 (55.1%) | 382 (57.7%) | 0.14 | NS | 0.82 (0.63–1.07) | 0.51 | NS | 0.90 (0.65–1.24) | | AG | 144 (41.4%) | 77 (38.8%) | 244 (36.9%) | 0.16 | NS | 1.21 (0.93–1.58) | 0.60 | NS | 1.09 (0.79–1.51) | | GG | 20 (5.7%) | 12 (6.1%) | 36 (5.4%) | 0.84 | NS | 1.06 (0.60–1.86) | 0.74 | NS | 1.12 (0.57–2.20) |
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OR = odds ratio; 95% CI = 95% confidence interval.
Pc = value adjusted by Bonferroni correction.
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