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BioMed Research International
Volume 2016, Article ID 5985903, 10 pages
http://dx.doi.org/10.1155/2016/5985903
Research Article

Valproic Acid Prevents Renal Dysfunction and Inflammation in the Ischemia-Reperfusion Injury Model

1Laboratory of Cellular, Genetic, and Molecular Nephrology, Renal Division, University of São Paulo, 01246-903 São Paulo, SP, Brazil
2Center for Cellular and Molecular Studies and Therapy (NETCEM), University of São Paulo, 01246-903 São Paulo, SP, Brazil

Received 27 December 2015; Revised 29 February 2016; Accepted 27 March 2016

Academic Editor: Peter A. McCullough

Copyright © 2016 Elerson C. Costalonga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Macedo and R. L. Mehta, “Preventing acute kidney injury,” Critical Care Clinics, vol. 31, no. 4, pp. 773–784, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Susantitaphong, D. N. Cruz, J. Cerda et al., “World incidence of AKI: a meta-analysis,” Clinical Journal of the American Society of Nephrology, vol. 8, no. 9, pp. 1482–1493, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. J. V. Bonventre and L. Yang, “Cellular pathophysiology of ischemic acute kidney injury,” Journal of Clinical Investigation, vol. 121, no. 11, pp. 4210–4221, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. S. R. Mulay, A. Linkermann, and H. Anders, “Necroinflammation in kidney disease,” Journal of the American Society of Nephrology, vol. 27, no. 1, pp. 27–39, 2015. View at Publisher · View at Google Scholar
  5. K. J. Kelly, W. W. Williams Jr., R. B. Colvin et al., “Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury,” The Journal of Clinical Investigation, vol. 97, no. 4, pp. 1056–1063, 1996. View at Publisher · View at Google Scholar · View at Scopus
  6. L. Li and M. D. Okusa, “Blocking the immune response in ischemic acute kidney injury: the role of adenosine 2A agonists,” Nature Clinical Practice Nephrology, vol. 2, no. 8, pp. 432–444, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Lee, S. Huen, H. Nishio et al., “Distinct macrophage phenotypes contribute to kidney injury and repair,” Journal of the American Society of Nephrology, vol. 22, no. 2, pp. 317–326, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. R. Di Paola, T. Genovese, D. Impellizzeri, A. Ahmad, S. Cuzzocrea, and E. Esposito, “The renal injury and inflammation caused by ischemia-reperfusion are reduced by genetic inhibition of TNF-αR1: a comparison with infliximab treatment,” European Journal of Pharmacology, vol. 700, no. 1–3, pp. 134–146, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. M. A. Glozak, N. Sengupta, X. Zhang, and E. Seto, “Acetylation and deacetylation of non-histone proteins,” Gene, vol. 363, no. 1-2, pp. 15–23, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. F. J. Dekker, T. van den Bosch, and N. I. Martin, “Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases,” Drug Discovery Today, vol. 19, no. 5, pp. 654–660, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Liu and S. Zhuang, “Treatment of chronic kidney diseases with histone deacetylase inhibitors,” Frontiers in Physiology, vol. 6, article 121, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. B. Monti, E. Polazzi, and A. Contestabile, “Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection,” Current Molecular Pharmacology, vol. 2, no. 1, pp. 95–109, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. T. Ichiyama, K. Okada, J. M. Lipton, T. Matsubara, T. Hayashi, and S. Furukawa, “Sodium valproate inhibits production of TNF-α and IL-6 and activation of NF-κB,” Brain Research, vol. 857, no. 1-2, pp. 246–251, 2000. View at Publisher · View at Google Scholar · View at Scopus
  14. Q. Zheng, W. Liu, Z. Liu, H. Zhao, X. Han, and M. Zhao, “Valproic acid protects septic mice from renal injury by reducing the inflammatory response,” Journal of Surgical Research, vol. 192, no. 1, pp. 163–169, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Zacharias, E. A. Sailhamer, Y. Li et al., “Histone deacetylase inhibitors prevent apoptosis following lethal hemorrhagic shock in rodent kidney cells,” Resuscitation, vol. 82, no. 1, pp. 105–109, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. N. M. Rogers, A. W. Thomson, and J. S. Isenberg, “Activation of parenchymal CD47 promotes renal ischemia-reperfusion injury,” Journal of the American Society of Nephrology, vol. 23, no. 9, pp. 1538–1550, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. I. L. Noronha, S. G. Oliveira, T. S. Tavares et al., “Apoptosis in kidney and pancreas allograft biopsies,” Transplantation, vol. 79, no. 9, pp. 1231–1235, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Dellê, J. R. C. Rocha, R. C. Cavaglieri, J. M. Vieira Jr., D. M. A. C. Malheiros, and I. L. Noronha, “Antifibrotic effect of tamoxifen in a model of progressive renal disease,” Journal of the American Society of Nephrology, vol. 23, no. 1, pp. 37–48, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. R. J. Ramalho, P. S. de Oliveira, R. C. Cavaglieri et al., “Hyperbaric oxygen therapy induces kidney protection in an ischemia/reperfusion model in rats,” Transplantation Proceedings, vol. 44, no. 8, pp. 2333–2336, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. L. V. B. Pereira, M. H. M. Shimizu, L. P. M. R. Rodrigues, C. C. Leite, L. Andrade, and A. C. Seguro, “N-Acetylcysteine protects rats with chronic renal failure from gadolinium-chelate nephrotoxicity,” PLoS ONE, vol. 7, no. 7, Article ID e39528, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. R. W. Speir, J. D. Stallings, J. M. Andrews, M. S. Gelnett, T. C. Brand, and S. K. Salgar, “Effects of Valproic acid and dexamethasone administration on early bio-markers and gene expression profile in acute kidney ischemia-reperfusion injury in the rat,” PLoS ONE, vol. 10, no. 5, Article ID e0126622, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. Z. Zhang, X. Qin, X. Zhao et al., “Valproic acid regulates antioxidant enzymes and prevents ischemia/reperfusion injury in the rat retina,” Current Eye Research, vol. 37, no. 5, pp. 429–437, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. M. K. Tso, E. Lass, J. Ai, and R. Loch Macdonald, “Valproic acid treatment after experimental subarachnoid hemorrhage,” in Neurovascular Events after Subarachnoid Hemorrhage, J. Fandino, S. Marbacher, A.-R. Fathi, C. Muroi, and E. Keller, Eds., vol. 120 of Acta Neurochirurgica Supplement, pp. 81–85, 2015. View at Publisher · View at Google Scholar
  24. Z. Wang, L.-K. Tsai, J. Munasinghe et al., “Chronic valproate treatment enhances postischemic angiogenesis and promotes functional recovery in a rat model of ischemic stroke,” Stroke, vol. 43, no. 9, pp. 2430–2436, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Brar, J. P. Singh, T. Kaur, S. Arora, and A. P. Singh, “Role of GABAergic activity of sodium valproate against ischemia-reperfusion-induced acute kidney injury in rats,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 387, no. 2, pp. 143–151, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Van Beneden, C. Geers, M. Pauwels et al., “Valproic acid attenuates proteinuria and kidney injury,” Journal of the American Society of Nephrology, vol. 22, no. 10, pp. 1863–1875, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. D.-I. Sinn, S.-J. Kim, K. Chu et al., “Valproic acid-mediated neuroprotection in intracerebral hemorrhage via histone deacetylase inhibition and transcriptional activation,” Neurobiology of Disease, vol. 26, no. 2, pp. 464–472, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. M. J. Burne, F. Daniels, A. El Ghandour et al., “Identification of the CD4+ T cell as a major pathogenic factor in ischemic acute renal failure,” The Journal of Clinical Investigation, vol. 108, no. 9, pp. 1283–1290, 2001. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Tang, Y. Yan, T. C. Zhao et al., “Class I HDAC activity is required for renal protection and regeneration after acute kidney injury,” American Journal of Physiology-Renal Physiology, vol. 307, no. 3, pp. F303–F316, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Chateauvieux, F. Morceau, M. Dicato, and M. Diederich, “Molecular and therapeutic potential and toxicity of valproic acid,” Journal of Biomedicine and Biotechnology, vol. 2010, Article ID 479364, 18 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. Z. Zhang, N. Tong, Y. Gong et al., “Valproate protects the retina from endoplasmic reticulum stress-induced apoptosis after ischemia-reperfusion injury,” Neuroscience Letters, vol. 504, no. 2, pp. 88–92, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. S.-Y. Wu, S.-E. Tang, F.-C. Ko, G.-C. Wu, K.-L. Huang, and S.-J. Chu, “Valproic acid attenuates acute lung injury induced by ischemia-reperfusion in rats,” Anesthesiology, vol. 122, no. 6, pp. 1327–1337, 2015. View at Publisher · View at Google Scholar · View at Scopus
  33. C. Wu, A. Li, Y. Leng, Y. Li, and J. Kang, “Histone deacetylase inhibition by sodium valproate regulates polarization of macrophage subsets,” DNA and Cell Biology, vol. 31, no. 4, pp. 592–599, 2012. View at Publisher · View at Google Scholar · View at Scopus
  34. K. Furuichi, T. Wada, Y. Iwata et al., “CCR2 signaling contributes to ischemia-reperfusion injury in kidney,” Journal of the American Society of Nephrology, vol. 14, no. 10, pp. 2503–2515, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. R. Kiernan, V. Brès, R. W. M. Ng et al., “Post-activation turn-off of NF-κB-dependent transcription is regulated by acetylation of p65,” The Journal of Biological Chemistry, vol. 278, no. 4, pp. 2758–2766, 2003. View at Publisher · View at Google Scholar · View at Scopus