Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2016, Article ID 6089430, 10 pages
http://dx.doi.org/10.1155/2016/6089430
Research Article

Aspirin Protects against Acinar Cells Necrosis in Severe Acute Pancreatitis in Mice

1Surgical Intensive Care Unit (SICU), Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, No. 305 Zhongshan East Road, Nanjing, Jiangsu Province 210002, China
2Department of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou, China
3Key Laboratory of Molecular Cardiovascular Science Ministry of Education, Institute of Cardiovascular Science, Peking University, Beijing, China
4Department of Emergency, Zhejiang Provincial People’s Hospital, Zhejiang, China

Received 11 July 2016; Revised 7 November 2016; Accepted 23 November 2016

Academic Editor: Andrea Mencarelli

Copyright © 2016 Guotao Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. G. Lankisch, M. Apte, and P. A. Banks, “Acute pancreatitis,” The Lancet, vol. 386, no. 9988, pp. 85–96, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. E. Afghani, S. J. Pandol, T. Shimosegawa et al., “Acute pancreatitis—progress and challenges: a report on an international symposium,” Pancreas, vol. 44, no. 8, pp. 1195–1210, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. E. Zerem, “Treatment of severe acute pancreatitis and its complications,” World Journal of Gastroenterology, vol. 20, no. 38, pp. 13879–13892, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. M. S. Petrov, S. Shanbhag, M. Chakraborty, A. R. J. Phillips, and J. A. Windsor, “Organ failure and infection of pancreatic necrosis as determinants of mortality in patients with acute pancreatitis,” Gastroenterology, vol. 139, no. 3, pp. 813–820, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. O. Meyrignac, S. Lagarde, B. Bournet et al., “Acute pancreatitis: extrapancreatic necrosis volume as early predictor of severity,” Radiology, vol. 276, no. 1, pp. 119–128, 2015. View at Publisher · View at Google Scholar · View at Scopus
  6. O. J. Bakker, H. C. van Santvoort, M. G. H. Besselink, E. Harst, H. S. Hofker, and H. G. Gooszen, “Prevention, detection, and management of infected necrosis in severe acute pancreatitis,” Current Gastroenterology Reports, vol. 11, no. 2, pp. 104–110, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. S. L. M. Das, J. I. C. Kennedy, R. Murphy, A. R. J. Phillips, J. A. Windsor, and M. S. Petrov, “Relationship between the exocrine and endocrine pancreas after acute pancreatitis,” World Journal of Gastroenterology, vol. 20, no. 45, pp. 17196–17205, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Vujasinovic, B. Tepes, J. Makuc et al., “Pancreatic exocrine insufficiency, diabetes mellitus and serum nutritional markers after acute pancreatitis,” World Journal of Gastroenterology, vol. 20, no. 48, pp. 18432–18438, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. T.-W. Ho, J.-M. Wu, T.-C. Kuo et al., “Change of both endocrine and exocrine insufficiencies after acute pancreatitis in non-diabetic patients: a nationwide population-based study,” Medicine (Baltimore), vol. 94, no. 27, p. e1123, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Y. Wick, “Aspirin: a history, a love story,” Consultant Pharmacist, vol. 27, no. 5, pp. 322–329, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. P. M. Rothwell, J. F. Price, F. G. R. Fowkes et al., “Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials,” The Lancet, vol. 379, no. 9826, pp. 1602–1612, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. L. Alfonso, G. Ai, R. C. Spitale, and G. J. Bhat, “Molecular targets of aspirin and cancer prevention,” British Journal of Cancer, vol. 111, no. 1, pp. 61–67, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Hussain, A. Javeed, M. Ashraf, Y. Zhao, M. M. Mukhtar, and M. U. Rehman, “Aspirin and immune system,” International Immunopharmacology, vol. 12, no. 1, pp. 10–20, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Berk, O. Dean, H. Drexhage et al., “Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness,” BMC Medicine, vol. 11, article 74, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. I. Akyazi, E. Eraslan, A. Gülçubuk et al., “Long-term aspirin pretreatment in the prevention of cerulein-induced acute pancreatitis in rats,” World Journal of Gastroenterology, vol. 19, no. 19, pp. 2894–2903, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Kleiber, “Body size and metabolic rate,” Physiological Reviews, vol. 27, no. 4, pp. 511–541, 1947. View at Google Scholar
  17. J. Liu, P. Xu, L. Zhang et al., “FTY720 attenuates acute pancreatitis in hypertriglyceridemic apolipoprotein CIII Transgenic mice,” Shock, vol. 44, no. 3, pp. 280–286, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. F. A. Gultekin, M. Kerem, E. Tatlicioglu, A. Aricioglu, C. Unsal, and N. Bukan, “Leptin treatment ameliorates acute lung injury in rats with cerulein-induced acute pancreatitis,” World Journal of Gastroenterology, vol. 13, no. 21, pp. 2932–2938, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. W. Xiao, K. Wu, M. Yin et al., “Wogonin inhibits tumor-derived regulatory molecules by suppressing STAT3 signaling to promote tumor immunity,” Journal of Immunotherapy, vol. 38, no. 5, pp. 167–184, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Cregger, A. J. Berger, and D. L. Rimm, “Immunohistochemistry and quantitative analysis of protein expression,” Archives of Pathology and Laboratory Medicine, vol. 130, no. 7, pp. 1026–1030, 2006. View at Google Scholar · View at Scopus
  21. G. Hu, J. Shen, L. Cheng et al., “Reg4 protects against acinar cell necrosis in experimental pancreatitis,” Gut, vol. 60, no. 6, pp. 820–828, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Liu, L. Yang, K.-L. Chen et al., “Knockdown of GRP78 promotes apoptosis in pancreatic acinar cells and attenuates the severity of cerulein and LPS induced pancreatic inflammation,” PLoS ONE, vol. 9, no. 3, Article ID e92389, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. J. M. Louhimo, M. L. Steer, and G. Perides, “Necroptosis is an important severity determinant and potential therapeutic target in experimental severe pancreatitis,” CMGH Cellular and Molecular Gastroenterology and Hepatology, vol. 2, no. 4, pp. 519–535, 2016. View at Publisher · View at Google Scholar
  24. X. Ma, D. J. Conklin, F. Li et al., “The oncogenic microRNA miR-21 promotes regulated necrosis in mice,” Nature Communications, vol. 6, article 7151, 2015. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. Liu, J. Yuan, T. Tan et al., “Genetic inhibition of protein kinase Cε attenuates necrosis in experimental pancreatitis,” American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 307, no. 5, pp. G550–G563, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. O. A. Mareninova, K.-F. Sung, P. Hong et al., “Cell death in pancreatitis: caspases protect from necrotizing pancreatitis,” Journal of Biological Chemistry, vol. 281, no. 6, pp. 3370–3381, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. A. S. Gukovskaya and S. J. Pandol, “Cell death pathways in pancreatitis and pancreatic cancer,” Pancreatology, vol. 4, no. 6, pp. 567–586, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. A. M. Kaiser, A. K. Saluja, A. Sengupta, M. Saluja, and M. L. Steer, “Relationship between severity, necrosis, and apoptosis in five models of experimental acute pancreatitis,” American Journal of Physiology—Cell Physiology, vol. 269, no. 5, pp. C1295–C1304, 1995. View at Google Scholar · View at Scopus
  29. J.-H. Ding, L.-Y. Yuan, R.-B. Huang, and G.-A. Chen, “Aspirin inhibits proliferation and induces apoptosis of multiple myeloma cells through regulation of Bcl-2 and Bax and suppression of VEGF,” European Journal of Haematology, vol. 93, no. 4, pp. 329–339, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Tian, Y. Ye, W. Gao et al., “Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6-STAT3 signaling pathway,” International Journal of Colorectal Disease, vol. 26, no. 1, pp. 13–22, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. L. Sun and X. Wang, “A new kind of cell suicide: mechanisms and functions of programmed necrosis,” Trends in Biochemical Sciences, vol. 39, no. 12, pp. 587–593, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. W. Zhou and J. Yuan, “SnapShot: necroptosis,” Cell, vol. 158, no. 2, p. 464.e1, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. L. Galluzzi, O. Kepp, and G. Kroemer, “RIP kinases initiate programmed necrosis,” Journal of Molecular Cell Biology, vol. 1, no. 1, pp. 8–10, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. S. He, L. Wang, L. Miao et al., “Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-α,” Cell, vol. 137, no. 6, pp. 1100–1111, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. J. Wu, Z. Huang, J. Ren et al., “Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis,” Cell Research, vol. 23, no. 8, pp. 994–1006, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. D. F. Barbeiro, M. K. Koike, A. M. M. Coelho, F. P. da Silva, and M. C. C. Machado, “Intestinal barrier dysfunction and increased COX-2 gene expression in the gut of elderly rats with acute pancreatitis,” Pancreatology, vol. 16, no. 1, pp. 52–56, 2016. View at Publisher · View at Google Scholar · View at Scopus
  37. G. Ozhan, T. H. Yanar, C. Ertekin, and B. Alpertunga, “The effect of genetic polymorphisms of cyclooxygenase 2 on acute pancreatitis in Turkey,” Pancreas, vol. 39, no. 3, pp. 371–376, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. S.-W. Seo, W.-S. Jung, T.-G. Piao et al., “Selective cyclooxygenase-2 inhibitor ameliorates cholecystokinin-octapeptide-induced acute pancreatitis in rats,” World Journal of Gastroenterology, vol. 13, no. 16, pp. 2298–2304, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. E. Alhan, N. I. Kalyoncu, C. Ercin, and B. V. Kural, “Effects of the celecoxib on the acute necrotizing pancreatitis in rats,” Inflammation, vol. 28, no. 5, pp. 303–309, 2004. View at Publisher · View at Google Scholar · View at Scopus
  40. W.-W. Yan, Z.-G. Zhou, Y.-D. Chen, and H.-K. Gao, “Role of COX-2 in microcirculatory disturbance in experimental pancreatitis,” World Journal of Gastroenterology, vol. 10, no. 14, pp. 2095–2098, 2004. View at Publisher · View at Google Scholar · View at Scopus
  41. J. L. J. De Almeida, J. Jukemura, A. M. M. Coelho, R. A. Patzina, M. C. C. Machado, and J. E. M. D. Cunha, “Inhibition of cyclooxygenase-2 in experimental severe acute pancreatitis,” Clinics, vol. 61, no. 4, pp. 301–306, 2006. View at Publisher · View at Google Scholar · View at Scopus