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BioMed Research International
Volume 2016, Article ID 6097417, 14 pages
http://dx.doi.org/10.1155/2016/6097417
Review Article

Oxidative Stress Relevance in the Pathogenesis of the Rheumatoid Arthritis: A Systematic Review

1Facultad de Ciencias de la Cultura Física, Universidad Autónoma de Chihuahua, Circuito No. 1, Nuevo Campus Universitario, Apartado Postal 1552, 31240 Chihuahua, CHIH, Mexico
2Facultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua, Circuito No. 1, Nuevo Campus Universitario, Apartado Postal 1552, 31240 Chihuahua, CHIH, Mexico

Received 27 November 2015; Revised 15 March 2016; Accepted 3 April 2016

Academic Editor: Kota V. Ramana

Copyright © 2016 Celia María Quiñonez-Flores et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease whose pathogenic mechanisms remain to be elucidated. The oxidative stress and antioxidants play an important role in the disease process of RA. The study of oxidants and antioxidants biomarkers in RA patients could improve our understanding of disease pathogenesis; likely determining the oxidative stress levels in these patients could prove helpful in assessing disease activity and might also have prognostic implications. To date, the usefulness of oxidative stress biomarkers in RA patients is unclear and the evidence supporting them is heterogeneous. In order to resume and update the information in the status of oxidants and antioxidants and their connection as biomarkers in RA, we performed a systematic literature search in the PubMed database, including clinical trials published in the last five years using the word combination “rheumatoid arthritis oxidative stress”. In conclusion, this review supports the fact that the oxidative stress is an active process in RA pathogenesis interrelated to other better known pathogenic elements. However, some controversial results preclude a definite conclusion.