Tricellular Tight Junctions in the Inner Ear

Figure 3

Time course of EP and endolymphatic [K⁺] elevation (modified from [38–41]) and hair cell degeneration in mice with mutations in TJ proteins. The arrowheads indicate the starting time for hair cell degeneration in each of the mutant mice models: cldn-9: claudin-9 mutant mice [18]; cldn-14: claudin-14 knockout mice [17]; ocln: occludin deficient mice [33]; ILDR1: ILDR1 null mice [34, 35]; Tric: tricellulin knockin mice [29] and knockout mice [36].