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BioMed Research International
Volume 2016, Article ID 6215745, 10 pages
Review Article

Eclectic Ocular Comorbidities and Systemic Diseases with Eye Involvement: A Review

1Ophthalmic Research Unit “Santiago Grisolía”, Fundación Investigación Biomédica y Sanitaria (FISABIO), Avenida Gaspar Aguilar 90, 46017 Valencia, Spain
2Ophthalmology Research Unit, Department of Surgery, Faculty of Medicine and Odontology, University of Valencia, Avenida Blasco Ibáñez 15, 46010 Valencia, Spain
3Spanish Net of Ophthalmic Pathology (OFTARED), Instituto de Salud Carlos III, C/Sinesio Delgado 4, 28029 Madrid, Spain
4Ophthalmology Department, University Hospital Reina Sofia, Avenida Intendente Jorge Palacios 1, 30003 Murcia, Spain
5Retina Division, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Nelson Building, 600 N. Wolf Street, Baltimore, MD 21287, USA
6Department of Ophthalmology, University and Polytechnic Hospital La Fe, Avenida Fernando Abril Martorell 106, 46026 Valencia, Spain
7Ophthalmic Unit, Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, 81 Oxford Street, 00133 Rome, Italy

Received 11 October 2015; Revised 1 January 2016; Accepted 1 February 2016

Academic Editor: Mitsuru Nakazawa

Copyright © 2016 María D. Pinazo-Durán et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Coexistence of several ocular diseases is more frequent than suspected. In spite of the refractive errors, one or more of the following can be detected simultaneously: glaucoma, cataracts, uveitis, age-related macular degeneration, and dry eyes. In addition, as people age, ocular comorbidities are much more usually seen. Specific diseases are openly acknowledged to affect the eyes and vision, such as diabetes mellitus, hypertension blood pressure, arthritis, hyperthyroidism, neurodegenerative disorders, hematologic malignancies, and/or systemic infections. Recent advances in early diagnosis and therapy of the ophthalmic pathologies have reinforced patient options to prevent visual impairment and blindness. Because of this, it is essential not to overlook sight-threatening conditions such as the ocular comorbidities and/or the eye involvement in the context of systemic disorders. Moreover, the important role of the multidisciplinary cooperation to improve and sustain management of patients affected with eclectic ocular comorbidities and/or systemic disorders with eye repercussion is specifically addressed. This review intends to shed light on these topics to help in making opportune diagnosis and appropriately managing the affected patients.