Emodin Inhibits the Epithelial to Mesenchymal Transition of Epithelial Ovarian Cancer Cells via ILK/GSK-3β/Slug Signaling Pathway
Emodin decreased the expression of ILK, p-GSK-3β, β-catenin, and Slug in A2780 and SK-OV-3 cells. (a, c) The expression of ILK, p-Akt, Akt, p-GSK-3β, GSK-3β, β-catenin, and Slug detected by Western blot analysis after treatment with emodin for 48 hours were shown. (b) Quantitative analyses of ILK protein expression in A2780 and SK-OV-3 cells shown in (a). , . (d) Quantitative analyses of factors in SK-OV-3 cells shown in (c). , .