Multiple Genetic Associations with Irish Wolfhound Dilated Cardiomyopathy

Table 6

Mode of penetrance for individual SNPs in relation to IWH DCM/AF.

	Chr1	Chr10	Chr15	Chr21	Chr37
Mode of penetrance	Multigenic	Multigenic	A dominant	G dominant	A recessive
Type of test	Allelic	Allelic	A dominant	G dominant	A recessive
Chi-squared test result	10.61	5.07	1.52	7.67	11.12
df	1	1	1	1	1
Bonferroni corrected	0.0056	0.12	1.00	0.028	0.0043
Published DCM allele	C	A	C	A	G
Current DCM/AF allele	C	C	A	G	A

Mode of penetrance, subsequent genetic association test used, chi-squared test result, degrees of freedom of the chi-squared test, and Bonferroni corrected value for each locus. Also shown are the alleles associated with IWH DCM in Philipp et al. [23] and IWH DCM/AF in the current study. Chr1 refers to the SNP on chromosome 1, Chr10 the SNP on chromosome 10, and so forth, as identified in Philipp et al. [23] and Table 1.