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BioMed Research International
Volume 2016, Article ID 6450124, 6 pages
Research Article

Cone Beam X-Ray Luminescence Tomography Imaging Based on KA-FEM Method for Small Animals

1College of Life Information Science and Instrument Engineering, Hangzhou Dianzi University, Hangzhou 310018, China
2School of Life Sciences and Technology, Xidian University, Xi’an 710071, China
3School of Information Sciences and Technology, Northwest University, Xi’an, Shaanxi 710069, China

Received 21 June 2016; Revised 6 September 2016; Accepted 5 October 2016

Academic Editor: Jinchao Feng

Copyright © 2016 Dongmei Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cone beam X-ray luminescence tomography can realize fast X-ray luminescence tomography imaging with relatively low scanning time compared with narrow beam X-ray luminescence tomography. However, cone beam X-ray luminescence tomography suffers from an ill-posed reconstruction problem. First, the feasibility of experiments with different penetration and multispectra in small animal has been tested using nanophosphor material. Then, the hybrid reconstruction algorithm with KA-FEM method has been applied in cone beam X-ray luminescence tomography for small animals to overcome the ill-posed reconstruction problem, whose advantage and property have been demonstrated in fluorescence tomography imaging. The in vivo mouse experiment proved the feasibility of the proposed method.