MicroRNAs: Novel Crossroads between Myeloma Cells and the Bone Marrow Microenvironment

Figure 1

Cross-talk between MM cells and the BM microenvironment. MM cells support BM angiogenesis and disrupt normal bone remodelling process. Moreover, BMSCs sustain MM survival and regulate osteogenesis and angiogenesis by direct contact between BM cellular components and MM cells or by releasing molecules.