Newly Developed Topical Cefotaxime Sodium Hydrogels: Antibacterial Activity and In Vivo Evaluation

Table 2

Physical properties of CTX topical gel formulations (F1–F13).

Formulations	Color	Homogeneity	Grittiness	pH	% drug content
F1	Opaque, yellowish	+++	—	6.6	96 ± 0.3
F2	Opaque, yellowish	+++	—	6.5	98.8 ± 0.1
F3	Translucent yellowish	+++	—	5.9	95.4 ± 0.2
F4	Translucent yellowish	+++	—	5.6	98.9 ± 0.3
F5	Translucent yellowish	+++	—	5.7	97.5 ± 0.4
F6	Translucent yellowish	+++	—	5.6	97.8 ± 0.1
F7	Opaque, buff	+++	—	4.0	98 ± 0.2
F8	Opaque, buff	+++	—	4.0	98.3 ± 0.1
F9	Shiny, transparent, yellowish	+++	—	6.2	97.5 ± 0.2
F10	Shiny, transparent, yellowish	Clumpy	—	6.3	95 ± 0.1
F11	Transparent	+++	—	5.7	98 ± 0.3
F12	Transparent	+++	—	5.9	97.8 ± 0.4
F13	Transparent	+++	—	6.3	96 ± 0.2

++: good; +++: very good; —: no grittiness.