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BioMed Research International
Volume 2016, Article ID 6725381, 12 pages
http://dx.doi.org/10.1155/2016/6725381
Research Article

Cornel Iridoid Glycoside Improves Locomotor Impairment and Decreases Spinal Cord Damage in Rats

Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing Institute for Brain Disorders, Beijing Engineering Research Center for Nerve System Drugs, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China

Received 23 June 2016; Revised 6 September 2016; Accepted 4 October 2016

Academic Editor: Sun-On Chan

Copyright © 2016 Wen-jing Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. M. Hagen, S. A. Lie, T. Rekand, N. E. Gilhus, and M. Gronning, “Mortality after traumatic spinal cord injury: 50 years of follow-up,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 81, no. 4, pp. 368–373, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. J. S. Krause, Y. Zhai, L. L. Saunders, and R. E. Carter, “Risk of mortality after spinal cord injury: an 8-year prospective study,” Archives of Physical Medicine and Rehabilitation, vol. 90, no. 10, pp. 1708–1715, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. A. M. Choo, J. Liu, M. Dvorak, W. Tetzlaff, and T. R. Oxland, “Secondary pathology following contusion, dislocation, and distraction spinal cord injuries,” Experimental Neurology, vol. 212, no. 2, pp. 490–506, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. B. K. Kwon, W. Tetzlaff, J. N. Grauer, J. Beiner, and A. R. Vaccaro, “Pathophysiology and pharmacologic treatment of acute spinal cord injury,” Spine Journal, vol. 4, no. 4, pp. 451–464, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. E. Park, A. A. Velumian, and M. G. Fehlings, “The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration,” Journal of Neurotrauma, vol. 21, no. 6, pp. 754–774, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Penas, M.-S. Guzmán, E. Verdú, J. Forés, X. Navarro, and C. Casas, “Spinal cord injury induces endoplasmic reticulum stress with different cell-type dependent response,” Journal of Neurochemistry, vol. 102, no. 4, pp. 1242–1255, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. J. K. Lee and B. Zheng, “Role of myelin-associated inhibitors in axonal repair after spinal cord injury,” Experimental Neurology, vol. 235, no. 1, pp. 33–42, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. W. B. J. Cafferty, P. Duffy, E. Huebner, and S. M. Strittmatter, “MAG and OMgp synergize with Nogo-A to restrict axonal growth and neurological recovery after spinal cord trauma,” Journal of Neuroscience, vol. 30, no. 20, pp. 6825–6837, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. E. Nyatia and D. M. Lang, “Localisation and expression of a myelin associated neurite inhibitor, Nogo-A and its receptor Nogo-receptor by mammalian CNS cells,” Research in Veterinary Science, vol. 83, no. 3, pp. 287–301, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. K. C. Wang, J. A. Kim, R. Sivasankaran, R. Segal, and Z. G. He, “p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp,” Nature, vol. 420, no. 6911, pp. 74–78, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Kubo, K. Hata, A. Yamaguchi, and T. Yamashita, “Rho-ROCK inhibitors as emerging strategies to promote nerve regeneration,” Current Pharmaceutical Design, vol. 13, no. 24, pp. 2493–2499, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. L. Tönges, J. C. Koch, M. Bähr, and P. Lingor, “ROCKing regeneration: Rho kinase inhibition as molecular target for neurorestoration,” Frontiers in Molecular Neuroscience, vol. 4, article 39, 2011. View at Publisher · View at Google Scholar
  13. N. Forgione and M. G. Fehlings, “Rho-ROCK inhibition in the treatment of spinal cord injury,” World Neurosurgery, vol. 82, no. 3, pp. E535–E539, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. L. McKerracher and H. Higuchi, “Targeting Rho to stimulate repair after spinal cord injury,” Journal of Neurotrauma, vol. 23, no. 3-4, pp. 309–317, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Q. Song and X. C. Zhang, “Experience analysis of using Cornus officinalis,” Jilin Journal of Traditional Chinese Medicine, vol. 26, no. 8, pp. 3–5, 2006. View at Google Scholar
  16. Y. W. Zhao, B. Zhang, W. L. Zhang, and Y. Q. Liu, “Rules of drug use for nourishing yin and tonifying the kidney to treat restoration stage of stroke,” Lishizhen Medicine and Materia Medica Research, vol. 21, no. 3, pp. 677–679, 2010. View at Google Scholar
  17. B.-L. Ya, C.-Y. Li, L. Zhang, W. Wang, and L. Li, “Cornel iridoid glycoside inhibits inflammation and apoptosis in brains of rats with focal cerebral ischemia,” Neurochemical Research, vol. 35, no. 5, pp. 773–781, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. R.-Q. Yao, L. Zhang, W. Wang, and L. Li, “Cornel iridoid glycoside promotes neurogenesis and angiogenesis and improves neurological function after focal cerebral ischemia in rats,” Brain Research Bulletin, vol. 79, no. 1, pp. 69–76, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. L.-H. Zhao, Y.-X. Ding, L. Zhang, and L. Li, “Cornel iridoid glycoside improves memory ability and promotes neuronal survival in fimbria-fornix transected rats,” European Journal of Pharmacology, vol. 647, no. 1–3, pp. 68–74, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. J. R. Plemel, G. Duncan, K.-W. K. Chen et al., “A graded forceps crush spinal cord injury model in mice,” Journal of Neurotrauma, vol. 25, no. 4, pp. 350–370, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. P. C. Poon, D. Gupta, M. S. Shoichet, and C. H. Tator, “Clip compression model is useful for thoracic spinal cord injuries: histologic and functional correlates,” Spine, vol. 32, no. 25, pp. 2853–2859, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. W. Liang, Q. Han, W. Jin et al., “The promotion of neurological recovery in the rat spinal cord crushed injury model by collagen-binding BDNF,” Biomaterials, vol. 31, no. 33, pp. 8634–8641, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. F. M. Bareyre, M. Kerschensteiner, O. Raineteau, T. C. Mettenleiter, O. Weinmann, and M. E. Schwab, “The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats,” Nature Neuroscience, vol. 7, no. 3, pp. 269–277, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Marsala, O. Kakinohana, T. L. Yaksh, Z. Tomori, S. Marsala, and D. Cizkova, “Spinal implantation of hNT neurons and neuronal precursors: graft survival and functional effects in rats with ischemic spastic paraplegia,” European Journal of Neuroscience, vol. 20, no. 9, pp. 2401–2414, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Cruz-Orengo, J. D. Figueroa, A. Torrado, A. Puig, S. R. Whittemore, and J. D. Miranda, “Reduction of EphA4 receptor expression after spinal cord injury does not induce axonal regeneration or return of tcMMEP response,” Neuroscience Letters, vol. 418, no. 1, pp. 49–54, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. D. M. Basso, M. S. Beattie, and J. C. Bresnahan, “A sensitive and reliable locomotor rating scale for open field testing in rats,” Journal of Neurotrauma, vol. 12, no. 1, pp. 1–21, 1995. View at Publisher · View at Google Scholar · View at Scopus
  27. K. A. Dunham, A. Siriphorn, S. Chompoopong, and C. L. Floyd, “Characterization of a graded cervical hemicontusion spinal cord injury model in adult male rats,” Journal of Neurotrauma, vol. 27, no. 11, pp. 2091–2106, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. R. A. Nishi, H. Liu, Y. Chu et al., “Behavioral, histological, and ex vivo magnetic resonance imaging assessment of graded contusion spinal cord injury in mice,” Journal of Neurotrauma, vol. 24, no. 4, pp. 674–689, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Piantino, J. A. Burdick, D. Goldberg, R. Langer, and L. I. Benowitz, “An injectable, biodegradable hydrogel for trophic factor delivery enhances axonal rewiring and improves performance after spinal cord injury,” Experimental Neurology, vol. 201, no. 2, pp. 359–367, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. H. J. G. Gundersen, E. B. V. Jensen, K. Kiêu, and J. Nielsen, “The efficiency of systematic sampling in stereology-reconsidered,” Journal of Microscopy, vol. 193, no. 3, pp. 199–211, 1999. View at Publisher · View at Google Scholar · View at Scopus
  31. M. D. Galvan, S. Luchetti, A. M. Burgos et al., “Deficiency in complement C1q improves histological and functional locomotor outcome after spinal cord injury,” The Journal of Neuroscience, vol. 28, no. 51, pp. 13876–13888, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. K. E. Moritz, K. Geeck, R. G. Underly, M. Searles, and J. S. Smith, “Post-operative environmental enrichment improves spatial and motor deficits but may not ameliorate anxiety- or depression-like symptoms in rats following traumatic brain injury,” Restorative Neurology and Neuroscience, vol. 32, no. 5, pp. 701–716, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. P. Chaovipoch, K. A. B. Jelks, L. M. Gerhold, E. J. West, S. Chongthammakun, and C. L. Floyd, “17β-estradiol is protective in spinal cord injury in post-and pre-menopausal rats,” Journal of Neurotrauma, vol. 23, no. 6, pp. 830–852, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. P. Kozlowski, D. Raj, J. Liu, C. Lam, A. C. Yung, and W. Tetzlaff, “Characterizing white matter damage in rat spinal cord with quantitative MRI and histology,” Journal of Neurotrauma, vol. 25, no. 6, pp. 653–676, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. R. W. Boyce, K.-A. Dorph-Petersen, L. Lyck, and H. J. G. Gundersen, “Design-based stereology: introduction to basic concepts and practical approaches for estimation of cell number,” Toxicologic Pathology, vol. 38, no. 7, pp. 1011–1025, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. E. Schültke, H. Kamencic, V. M. Skihar, R. Griebel, and B. Juurlink, “Quercetin in an animal model of spinal cord compression injury: correlation of treatment duration with recovery of motor function,” Spinal Cord, vol. 48, no. 2, pp. 112–117, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. J. E. Pereira, L. M. Costa, A. M. Cabrita et al., “Methylprednisolone fails to improve functional and histological outcome following spinal cord injury in rats,” Experimental Neurology, vol. 220, no. 1, pp. 71–81, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. S. M. Garraway, J. D. Turtle, J. R. Huie et al., “Intermittent noxious stimulation following spinal cord contusion injury impairs locomotor recovery and reduces spinal brain-derived neurotrophic factor-tropomyosin-receptor kinase signaling in adult rats,” Neuroscience, vol. 199, pp. 86–102, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. D. S. K. Magnuson, R. Lovett, C. Coffee et al., “Functional consequences of lumbar spinal cord contusion injuries in the adult rat,” Journal of Neurotrauma, vol. 22, no. 5, pp. 529–543, 2005. View at Publisher · View at Google Scholar · View at Scopus
  40. S. M. Onifer, Y. P. Zhang, D. A. Burke et al., “Adult rat forelimb dysfunction after dorsal cervical spinal cord injury,” Experimental Neurology, vol. 192, no. 1, pp. 25–38, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. Q. Cao, Y. P. Zhang, C. Iannotti et al., “Functional and electrophysiological changes after graded traumatic spinal cord injury in adult rat,” Experimental Neurology, vol. 191, supplement 1, pp. S3–S16, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. G. C. Koopmans, R. Deumens, A. Buss et al., “Acute rolipram/thalidomide treatment improves tissue sparing and locomotion after experimental spinal cord injury,” Experimental Neurology, vol. 216, no. 2, pp. 490–498, 2009. View at Publisher · View at Google Scholar · View at Scopus
  43. C. Su, D. Zhang, J. Truong et al., “Effects of a novel herbal formulation JSK on acute spinal cord injury in rats,” Restorative Neurology and Neuroscience, vol. 31, no. 5, pp. 597–617, 2013. View at Publisher · View at Google Scholar · View at Scopus
  44. S. Grillner, “The motor infrastructure: from ion channels to neuronal networks,” Nature Reviews Neuroscience, vol. 4, no. 7, pp. 573–586, 2003. View at Publisher · View at Google Scholar · View at Scopus
  45. N. Wang and L. Li, “Effects of cornel iridoid glycoside on inflammatory reaction in the brain of traumatic brain injury rat model,” Chinese Journal of Clinical Pharmacology and Therapeutics, vol. 15, no. 3, pp. 255–259, 2010. View at Google Scholar
  46. R. Deumens, G. C. Koopmans, and E. A. J. Joosten, “Regeneration of descending axon tracts after spinal cord injury,” Progress in Neurobiology, vol. 77, no. 1-2, pp. 57–89, 2005. View at Publisher · View at Google Scholar · View at Scopus
  47. M. L. Starkey, A. W. Barritt, P. K. Yip et al., “Assessing behavioural function following a pyramidotomy lesion of the corticospinal tract in adult mice,” Experimental Neurology, vol. 195, no. 2, pp. 524–539, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. R. V. Krishnan, R. Muthusamy, and V. Sankar, “Spinal cord injury repair research: a new combination treatment strategy,” International Journal of Neuroscience, vol. 108, no. 3-4, pp. 201–207, 2001. View at Publisher · View at Google Scholar · View at Scopus
  49. O. Raineteau, K. Fouad, P. Noth, M. Thallmair, and M. E. Schwab, “Functional switch between motor tracts in the presence of the mAB IN-1 in the adult rat,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 12, pp. 6929–6934, 2001. View at Publisher · View at Google Scholar · View at Scopus
  50. A. Chen, H. Wang, J. Zhang et al., “BYHWD rescues axotomized neurons and promotes functional recovery after spinal cord injury in rats,” Journal of Ethnopharmacology, vol. 117, no. 3, pp. 451–456, 2008. View at Publisher · View at Google Scholar · View at Scopus
  51. N. Weishaupt, A. L. O. Mason, C. Hurd et al., “Vector-induced NT-3 expression in rats promotes collateral growth of injured corticospinal tract axons far rostral to a spinal cord injury,” Neuroscience, vol. 272, pp. 65–75, 2014. View at Publisher · View at Google Scholar · View at Scopus
  52. M. T. Filbin, “Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS,” Nature Reviews Neuroscience, vol. 4, no. 9, pp. 703–713, 2003. View at Publisher · View at Google Scholar · View at Scopus
  53. M. S. Chen, A. B. Huber, M. E. Van Der Haar et al., “Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1,” Nature, vol. 403, no. 6768, pp. 434–439, 2000. View at Publisher · View at Google Scholar · View at Scopus
  54. B. S. Bregman, E. Kunkel-Bagden, L. Schnell, H. N. Dai, D. Gao, and M. E. Schwab, “Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors,” Nature, vol. 378, no. 6556, pp. 498–501, 1995. View at Publisher · View at Google Scholar · View at Scopus
  55. R. J. Giger, K. Venkatesh, O. Chivatakarn et al., “Mechanisms of CNS myelin inhibition: evidence for distinct and neuronal cell type specific receptor systems,” Restorative Neurology and Neuroscience, vol. 26, no. 2-3, pp. 97–115, 2008. View at Google Scholar · View at Scopus
  56. S. Casha, W. R. Yu, and M. G. Fehlings, “Oligodendroglial apoptosis occurs along degenerating axons and is associated with FAS and p75 expression following spinal cord injury in the rat,” Neuroscience, vol. 103, no. 1, pp. 203–218, 2001. View at Publisher · View at Google Scholar · View at Scopus
  57. M. G. Fehlings, N. Theodore, J. Harrop et al., “A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury,” Journal of Neurotrauma, vol. 28, no. 5, pp. 787–796, 2011. View at Publisher · View at Google Scholar · View at Scopus