Acute Kidney Injury Classified by Serum Creatinine and Urine Output in Critically Ill Cancer Patients

Table 2

Multivariate Cox-regression analyses for factors associated with 6-month mortality by using different AKI criteria.

	Model 1: SCr alone			Model 2: UO alone			⁢Model 3: maximum grade by SCr or UO			Model 4: SCr, OU, or both criteria
	HR	95% CI	value	HR	95% CI	value	HR	95% CI	value		HR	95% CI	value
Characteristics at ICU admission
Male gender	1.23	0.87–1.74	0.243	1.18	0.84–1.67	0.339	1.21	0.86–1.72	0.278		1.18	0.83–1.69	0.350
Age (years)	1.00	0.99–1.01	0.881	1.00	0.98–1.01	0.334	1.00	0.99–1.01	0.582		1.00	0.99–1.01	0.668
Hospital days prior to ICU	1.00	0.98–1.02	0.825	1.00	0.98–1.02	0.768	1.00	0.98–1.02	0.973		1.00	0.98–1.02	0.946
Sepsis	1.21	0.85–1.71	0.295	1.27	0.90–1.79	0.171	1.16	0.82–1.64	0.403		1.20	0.85–1.71	0.299
Leukopenia	1.88	1.22–2.88	0.004	1.85	1.22–2.82	0.004	1.78	1.16–2.74	0.009		1.87	1.22–2.87	0.004
Malignancy
Hematologic malignancy	1.47	0.98–2.22	0.067	1.50	1.01–2.24	0.045	1.42	0.94–2.14	0.095		1.52	1.01–2.30	0.047
Neoplasm extension	1.62	1.16–2.25	0.004	1.64	1.18–2.27	0.003	1.59	1.14–2.20	0.006		1.66	1.20–2.30	0.002
ECOG	1.18	1.02–1.37	0.027	1.15	0.99–1.34	0.073	1.15	0.99–1.33	0.060		1.17	1.01–1.36	0.037
ICU hospitalization
Mechanical ventilation	2.60	1.66–4.07	<0.001	2.30	1.43–3.67	<0.001	2.38	1.52–3.72	<0.001		2.14	1.35–3.40	<0.001
Vasopressor	1.36	0.89–2.07	0.162	1.45	0.96–2.19	0.081	1.28	0.85–1.94	0.237		1.33	0.88–2.01	0.173
Acute kidney injury
No AKI		Ref	Ref		Ref	Ref		Ref	Ref	No AKI		Ref	Ref
Stage 1 AKI	1.70	1.07–2.70	0.025	1.34	0.83–2.15	0.230	2.04	1.14–3.68	0.017	SC	2.48	1.30–4.76	0.006
Stage 2 AKI	1.98	1.22–3.21	0.006	2.19	1.36–3.54	0.001	2.73	1.53–4.88	0.001	UO	2.24	1.26–4.09	0.009
Stage 3 AKI	2.33	1.50–3.61	<0.001	4.18	2.52–6.92	<0.001	4.50	2.52–8.02	<0.001	Both	3.56	2.03–6.24	<0.001

AKI: acute kidney injury; SCr: serum creatinine; UO: urinary output.
Both Refer to patients who fulfilled SCr elevation and UO criteria.