Reproductive Toxicities Caused by Swainsonine from Locoweed in Mice

Table 1

Body and reproductive organ weights of female mice given swainsonine during the estrous cycle.

		Body weight (g)	Ovarian index	Uterus index	Estrous cycle (day)	Number of estrous mice
Day 7	2.50 mg/kg BW	^a	^a	^a	^a	^a
	1.20 mg/kg BW	^b	^a	^a	^a	^a
	0.60 mg/kg BW	^c	^b	^a	^b	^b
	0 mg/kg BW	^d	^c	^b	^c	^c
Day 15	2.50 mg/kg BW	^a	^a	^a	^a	^a
	1.20 mg/kg BW	^b	^a	^a	^b	^b
	0.60 mg/kg BW	^c	^b	^b	^c	^c
	0 mg/kg BW	^d	^c	^c	^d	^d

The values are the mean SD.
Ovary viscera index = ovary weight/body weight × 100 (mg/g).
Uterus viscera index = uterus weight/body weight × 100 (mg/g).
Significantly different from each dosage group of same generation .