Reproductive Toxicities Caused by Swainsonine from Locoweed in Mice

Table 3

Developmental findings for mice given swainsonine by intraperitoneal injection.

	Number of live pups on PND 0 (%)	Number of live pups on PND 4 (%)	Number of live pups on PND 15 (%)	Body weights of live pups on PND 0 (g)	Body weights of live pups on PND 4 (g)	Body weights of live pups on PND 15 (g)
F0-I	^a	^a	^a	^a	^a	^a
F0-II	^a	^ab	^a	^a	^a	^a
F0-III	^a	^b	^b	^a	^a	^a
F0-IV	^b	^c	^c	^b	^b	^b
F1-I	^a	^a	^a	^a	^a	^a
F1-II	^ab	^ab	^a	^a	^a	^a
F1-III	^b	^b	^b	^a	^a	^a
F1-IV	^c	^c	^c	^b	^b	^b

The number of live pups on PND 0 (%) = number of live pups on PND 0/total number of pups born 100 postnatal day (PND). The number of live pups on PND 4 (%) number of live pups on PND 4/total number of pups born 100. The number of live pups on PND 15 (%) number of live pups on PND 15/total number of pups born 100. The sex ratio of live pups number of live males/total number of live pups.
The values are the mean SD. Significantly different from each dose group for the same generation .