Reproductive Toxicities Caused by Swainsonine from Locoweed in Mice

Table 4

Reproductive findings in mice given swainsonine by intraperitoneal injection.

	Number of pairs	Number of pairs with successful copulation	Copulation index	Number of pregnant females	Fertility index	Gestation index	Gestation length (days)
F0-I	10	7.56^a	75.6^a	7.41	98.02^A	83^A	^A
F0-II	10	8.34^ab	83.4^ab	8.11	97.24^A	90^A	^A
F0-III	10	8.86^b	88.6^b	8.77	98.98^A	96^A	^A
F0-IV	10	9.87^c	98.7^c	9.87	100^A	100^A	^A
F1-I	10	7.20^a	72.0^a	6.32	87.78^B	76^B	^A
F1-II	10	7.98^ab	79.8^ab	6.91	86.59^B	85^B	^A
F1-III	10	8.23^b	82.3^b	7.32	88.94^B	93^B	^A
F1-IV	10	9.93^c	99.3^c	9.93	100^A	100^A	^A

The values are the mean SD. The copulation index (%) number of copulated rats/number of pairs 100. The fertility index (%) number of pregnant females/number of pairs with successful copulation 100. The gestation index (%) number of dams with live pups/number of pregnant females 100.
Significantly different from each dose group for the same generation .
Significantly different from each dose group for different generations .