Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2016, Article ID 6824719, 7 pages
http://dx.doi.org/10.1155/2016/6824719
Research Article

Rebamipide, an Amino Acid Analog of 2(1H)-Quinolinone, Inhibits the Formation of Human Osteoclasts

Institute of Rheumatology, Tokyo Women’s Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo 162-0054, Japan

Received 3 August 2016; Accepted 20 October 2016

Academic Editor: Yi-Ping Liu

Copyright © 2016 Yuki Nanke et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Schubert, “Matchmaking service links up researchers to wallflower drugs,” Nature Medicine, vol. 16, article 7, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Mundy, R. Garrett, S. Harris et al., “Stimulation of bone formation in vitro and in rodents by statins,” Science, vol. 286, no. 5446, pp. 1946–1949, 1999. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. Nanke, S. Kotake, H. Akama, and N. Kamatani, “Alkaline phosphatase in rheumatoid arthritis patients: possible contribution of bone-type ALP to the raised activities of ALP in rheumatoid arthritis patients,” Clinical Rheumatology, vol. 21, no. 3, pp. 198–202, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Kotake, N. Udagawa, N. Takahashi et al., “IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis,” The Journal of Clinical Investigation, vol. 103, no. 9, pp. 1345–1352, 1999. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Kotake, Y. Nanke, M. Mogi et al., “IFN-γ-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL,” European Journal of Immunology, vol. 35, no. 11, pp. 3353–3363, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Nanke, S. Kotake, T. Ninomiya, T. Furuya, H. Ozawa, and N. Kamatani, “Geranylgeranylacetone inhibits formation and function of human osteoclasts and prevents bone loss in tail-suspended rats and ovariectomized rats,” Calcified Tissue International, vol. 77, no. 6, pp. 376–385, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. Nanke, M. Kawamoto, T. Yago, J. Chiba, H. Yamanaka, and S. Kotake, “Geranylgeranylacetone, a non-toxic inducer of heat shock protein, induces cell death in fibroblast-like synoviocytes from patients with rheumatoid arthritis,” Modern Rheumatology, vol. 19, no. 4, pp. 379–383, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Yamasaki, T. Kanbe, T. Chijiwa, H. Ishiyama, and S. Morita, “Gastric mucosal protection by OPC-12759, a novel antiulcer compound, in the rat,” European Journal of Pharmacology, vol. 142, no. 1, pp. 23–29, 1987. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Kleine, S. Kluge, and B. M. Peskar, “Stimulation of prostaglandin biosynthesis mediates gastroprotective effect of rebamipide in rats,” Digestive Diseases and Sciences, vol. 38, no. 8, pp. 1441–1449, 1993. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Yoshikawa, Y. Naito, T. Tanigawa, and M. Kondo, “Free radical scavenging activity of the novel anti-ulcer agent rebamipide studied by electron spin resonance,” Drug Research, vol. 43, no. 3, pp. 363–366, 1993. View at Google Scholar · View at Scopus
  11. M. Aihara, A. Azuma, H. Takizawa et al., “Molecular analysis of suppression of interleukin-8 production by rebamipide in Helicobacter pylori-stimulated gastric cancer cell lines,” Digestive Diseases and Sciences, vol. 43, no. 9, pp. 174–180, 1998. View at Google Scholar · View at Scopus
  12. H. Bamba, S. Ota, A. Kato et al., “Effect of rebamipide on prostaglandin receptors-mediated increase of inflammatory cytokine production by macrophages,” Alimentary Pharmacology and Therapeutics, vol. 18, no. 1, pp. 113–118, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. K. J. Livak and T. D. Schmittgen, “Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method,” Methods, vol. 25, no. 4, pp. 402–408, 2001. View at Publisher · View at Google Scholar
  14. Y. Naito, T. Yoshikawa, S. Iinuma et al., “Local gastric and serum concentrations of rebamipide following oral administration to patients with chronic gastritis,” Drug Research, vol. 46, no. 7, pp. 698–700, 1996. View at Google Scholar · View at Scopus
  15. K. Ishihara, Y. Komuro, N. Nishiyama, K. Yamasaki, and K. Hotta, “Effect of rebamipide on mucus secretion by endogenous prostaglandin-independent mechanism in rat gastric mucosa,” Drug Research, vol. 42, no. 12, pp. 1462–1466, 1992. View at Google Scholar · View at Scopus
  16. Y. Naito, T. Yoshikawa, T. Tanigawa et al., “Hydroxyl radical scavenging by rebamipide and related compounds: electron paramagnetic resonance study,” Free Radical Biology and Medicine, vol. 18, no. 1, pp. 117–123, 1995. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Yoshida, T. Yoshikawa, S. Iinuma et al., “Rebamipide protects against activation of neutrophils by Helicobacter pylori,” Digestive Diseases and Sciences, vol. 41, no. 6, pp. 1139–1144, 1996. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Naito, M. Kuroda, K. Mizushima et al., “Transcriptome analysis for cytoprotective actions of rebamipide against indomethacin-induced gastric mucosal injury in rats,” Journal of Clinical Biochemistry and Nutrition, vol. 41, no. 3, pp. 202–210, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Kinjo, H. Kawanaka, T. Akahoshi et al., “Significance of ERK nitration in portal hypertensive gastropathy and its therapeutic implications,” American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 295, no. 5, pp. G1016–G1024, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. T. Nishizawa, H. Suzuki, I. Nakagawa et al., “Rebamipide-promoted restoration of gastric mucosal sonic hedgehog expression after early Helicobacter pylori eradication,” Digestion, vol. 79, no. 4, pp. 259–262, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Naito and T. Yoshikawa, “Rebamipide: a gastrointestinal protective drug with pleiotropic activities,” Expert Review of Gastroenterology & Hepatology, vol. 4, no. 3, pp. 261–270, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. J.-Y. Choe, K.-Y. Park, S.-J. Lee, S.-H. Park, and S.-K. Kim, “Rebamipide inhibits tumor necrosis factor-α-induced interleukin-8 expression by suppressing the NF-κB signal pathway in human umbilical vein endothelial cells,” Inflammation Research, vol. 59, no. 12, pp. 1019–1026, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. C. D. Kim, Y. K. Kim, S. H. Lee, and K. W. Hong, “Rebamipide inhibits neutrophil adhesion to hypoxia/reoxygenation-stimulated endothelial cells via nuclear factor-κB-dependent pathway,” Journal of Pharmacology and Experimental Therapeutics, vol. 294, no. 3, pp. 864–869, 2000. View at Google Scholar · View at Scopus
  24. M. Kohashi, N. Ishimaru, R. Arakaki, and Y. Hayashi, “Effective treatment with oral administration of rebamipide in a mouse model of Sjögren's syndrome,” Arthritis & Rheumatism, vol. 58, no. 2, pp. 389–400, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. S.-J. Moon, J.-S. Park, Y.-J. Woo et al., “Rebamipide suppresses collagen-induced arthritis through reciprocal regulation of Th17/Treg cell differentiation and heme oxygenase 1 induction,” Arthritis and Rheumatology, vol. 66, no. 4, pp. 874–885, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. J.-K. Byun, S.-J. Moon, J.-Y. Jhun et al., “Rebamipide attenuates autoimmune arthritis severity in SKG mice via regulation of B cell and antibody production,” Clinical and Experimental Immunology, vol. 178, no. 1, pp. 9–19, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Shioya, E. Kashiyama, K. Okada et al., “Metabolic fate of the anti-ulcer agent, absorption, distribution and excretion in rats and dogs,” Iyakuhin Kenkyu, vol. 20, pp. 522–533, 1989. View at Google Scholar
  28. M. Suzuki, S. Miura, M. Mori et al., “Rebamipide, a novel antiulcer agent, attenuates Helicobacter pylori induced gastric mucosal cell injury associated with neutrophil derived oxidants,” Gut, vol. 35, no. 10, pp. 1375–1378, 1994. View at Publisher · View at Google Scholar · View at Scopus