Analyses of Genetic Variations of Glutathione S-Transferase Mu1 and Theta1 Genes in Bangladeshi Tannery Workers and Healthy Controls

Figure 3

Distribution of GST activity in different genotypes of tannery workers (TW) and healthy controls (C). GST activity varied in different genotypes. The activity was found higher in individuals having both the alleles for GSTM1 and GSTT1 genes. On the other hand, GST activity was found lower in individuals having allele for either GSTM1 or GSTT1 gene (+/−, GSTT1 null genotypes; −/+, GSTTM1 null genotypes). Interestingly, GST activity was also found higher in individuals with null alleles (−/−) for both the GSTM1 and GSTT1 genes. The bars represent the standard deviation of GST activities of each genotype and the GST activities (expressed as U/L) were calculated from the average of two independent experiments for each sample. Values within the bar represent the percentages of respective genotypes in the studied population.