Bioartificial Therapy of Sepsis: Changes of Norepinephrine-Dosage in Patients and Influence on Dynamic and Cell Based Liver Tests during Extracorporeal Treatments

Table 4

Hemodynamic parameters, central venous oxygen saturation, dynamic measurement of the liver function (LiMON-System), and lactate before and after the extracorporeal granulocyte therapy (median/0.25–0.75 quartile) measured with the PiCCO-System (under significant reduction of norepinephrine; see Figure 2).

	Before extracorporeal therapy ()	After extracorporeal therapy ()	Statistical significance
CI (L/m^2/min)	3.1 (2.3–3.8)	3.5 (2.9–3.7)	n.s.
SVI (mL/m^2)	42 (33–56)	45 (40–52)	n.s.
MAP (mmHg)	73 (65–83)	74 (66–79)	n.s.
Heart rate (beat/min)	73 (67–95)	76 (70–85)	n.s.
SVRI (dyne × sec × cm^−5/m^2)	1510 (1150–1730)	1290 (1130–1760)	n.s.
ITBVI (mL/m^2)	1060 (930–1160)	1000 (960–1120)	n.s.
EVLWI (mL/kg)	7.6 (6.8–9.4)	7.5 (6.5–8.3)	n.s.
cvSpO2 (%)	73.5 (68.4–76.5)	71.5 (68.6–79.1)	n.s.
Lactate (mmol/L)	1.5 (1.2–3.0)	1.3 (1.0–2.7)	n.s.
ICG-PDR (%)/ICG-PDR/CI	13.8 (11.9–15.6.)/4.4 (3.1–5.1)	14.2 (12.4–17.1)/4.6 (3.1–4.8)	n.s./n.s.

CI: cardiac index.
cvSpO2: central venous oxygen saturation.
EVLWI: extravascular lung water index.
ICG-PDR: indocyanine green plasma disappearance rate.
ITBVI: intrathoracic blood volume index.
MAP: mean arterial pressure.
n.s.: not (statistically) significant.
SVI: stroke volume index.
SVRI: systemic vascular resistance index.