Review Article

Versatility of Approximating Single-Particle Electron Microscopy Density Maps Using Pseudoatoms and Approximation-Accuracy Control

Figure 5

Denoising of EM density maps based on their approximation to a desired level of accuracy () using 3D Gaussian functions of a given standard deviation (). (a and b) Half of the density map of genogroup II genotype 10 norovirus virus-like particle from [60] radially colored with Chimera before (a) and after (b) denoising (denoising based on and ). (c and d) Density-map arbitrary slice before (c) and after (d) denoising, for the density maps shown in (a) and (b), respectively. Reproduced with permission from [44].
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