TY - JOUR
A2 - Paraskevas, Kosmas
AU - Cyganek, Anna
AU - Wyczalkowska-Tomasik, Aleksandra
AU - Jarmuzek, Patrycja
AU - Grzechocinska, Barbara
AU - Jabiry-Zieniewicz, Zoulikha
AU - Paczek, Leszek
AU - Wielgos, Miroslaw
PY - 2016
DA - 2016/01/20
TI - Activity of Proteolytic Enzymes and Level of Cystatin C in the Peripartum Period
SP - 7065821
VL - 2016
AB - Objectives. The aim of the study was to evaluate the activity of cathepsin B, collagenases, trypsin, and plasmin and concentration of cystatin C in serum of healthy pregnant women in peripartum period. Study Design. The study group included 45 women in uncomplicated pregnancies. Blood samples were collected in four time points. Enzyme activity was measured by spectrofluorometric method. The level of cystatin C was measured using immunonephelometric method. Results. Mean activity of cathepsin B and the level of serum cystatin C were significantly higher in the study group. Collagenase activity was significantly lower in the study group than the control group. No differences in collagenase, plasmin, and trypsin activity on each day of the peripartum period were found. Conclusion. High activity of cathepsin B and increased level of cystatin C are typical for women in late pregnancy. Those levels significantly decrease after delivery which can be associated with potential role of those markers in placental separation. The insignificant changes of cystatin C level in the peripartum period seem to exclude the possibility of using cystatin C as a marker for renal insufficiency in the peripartum period but additional research is necessary to investigate the matter further.
SN - 2314-6133
UR - https://doi.org/10.1155/2016/7065821
DO - 10.1155/2016/7065821
JF - BioMed Research International
PB - Hindawi Publishing Corporation
KW -
ER -