Identification of Novel Inhibitors against Coactivator Associated Arginine Methyltransferase 1 Based on Virtual Screening and Biological Assays

Table 1

Chemical structures and inhibitory activity (, ) of selected compounds based on virtual screening against CARM1 and several other PRMTs.

Compound ID	Specs ID	Compound structure	IC50 (μM)
			CARM1	PRMT1	PRMT6
DC_C66	AQ-405/42300312		1.8	21	47
DC_C11	AQ-405/42300392		15	36	41

All assays were conducted in duplicate.