A Systematic Framework for Drug Repositioning from Integrated Omics and Drug Phenotype Profiles Using Pathway-Drug Network

Figure 6

Known drugs and promising drug candidates on the validation network. The validation network for 16 drugs was constructed from STITCH. Each node is a drug or a gene. The green edges represent drug-gene interactions, and the red edges indicate drug-drug interactions; the blue edges represent gene-gene relationships obtained from STRING. Wider edges reflect stronger relationships between nodes. For easier implementation and visualization, a maximum of 40 neighbors of drugs (17 nodes) with a weight criterion of were selected. As indicated in the figure, some drugs have significant topological features on the validation network.