A Systematic Framework for Drug Repositioning from Integrated Omics and Drug Phenotype Profiles Using Pathway-Drug Network
Table 9
The neighbors of candidate drug “MS-257” on the validation network.
Genes
Description
Weight
HDAC1
Histone deacetylase 1; responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression, and developmental events.
0.987
TP53
Tumor protein p53: it acts as a tumor suppressor in many tumor types and induces growth arrest or apoptosis depending on the physiological circumstances and cell type.
0.831
CASP3
Caspase 3, apoptosis-related cysteine peptidase; involved in the activation cascade of caspases responsible for apoptosis execution.
0.827
CCND1
cyclin D1; essential for the control of the cell cycle at the G1/S (start) transition.
0.822
CYP3A4
Cytochrome P450, family 3, subfamily A, polypeptide 4; cytochromes P450 are a group of heme-thiolate monooxygenases.
