Research Article

Establishment of Simple and Routine Methods in Early Diagnosis of Gentamicin-Induced Kidney Injury Based on a Rat Model

Table 2

Urinary pH and SG of rats treated with different GM dosage and duration.

ItemsDosage (mg⋅kg−1)Duration
Day 1Day 3Day 7Day 14

pH07.625 ± 0.8997.833 ± 0.7077.500 ± 1.0417.750 ± 0.354
47.417 ± 0.9707.500 ± 0.7646.833 ± 0.7076.786 ± 0.735
207.500 ± 0.5247.000 ± 0.7586.643 ± 0.7036.570 ± 0.418
1007.250 ± 0.6416.800 ± 0.7805.000 ± 1.140

SG01.022 ± 0.0041.025 ± 0.0031.023 ± 0.0031.024 ± 0.004
41.023 ± 0.0051.027 ± 0.0071.028 ± 0.0041.027 ± 0.004
201.025 ± 0.0051.028 ± 0.0021.028 ± 0.0031.028 ± 0.003
1001.027 ± 0.0041.030 ± 0.0051.030 ± 0.005

Values are expressed as mean ± SD for five rats in each group.
Groups: control (0 mg⋅kg−1) group, 4 mg⋅kg−1 GM group, 20 mg⋅kg−1 GM group, and 100 mg⋅kg−1 GM group.
versus 0 mg⋅kg−1 groups.
versus 100 mg⋅kg−1 GM groups.