Establishment of Simple and Routine Methods in Early Diagnosis of Gentamicin-Induced Kidney Injury Based on a Rat Model
Table 4
Kidney coefficient of rats treated with different GM dosage and duration.
Kidney coefficient
Dosage (mg⋅kg−1)
Duration
1st day
3rd day
7th day
14th day
Left kidney
0
0.449 ± 0.088
0.351 ± 0.006
0.385 ± 0.059
0.360 ± 0.005
4
0.385 ± 0.018
0.397 ± 0.029
0.421 ± 0.037
0.417 ± 0.069
20
0.411 ± 0.074
0.378 ± 0.060
0.438 ± 0.038
0.382 ± 0.050
100
0.424 ± 0.007
0.377 ± 0.047
0.440 ± 0.076
0.486 ± 0.038
Right kidney
0
0.428 ± 0.037
0.340 ± 0.029
0.389 ± 0.034
0.387 ± 0.032
4
0.357 ± 0.010
0.395 ± 0.054
0.464 ± 0.63
0.432 ± 0.073
20
0.380 ± 0.025
0.373 ± 0.022
0.476 ± 0.025
0.383 ± 0.043
100
0.389 ± 0.035
0.389 ± 0.056
0.454 ± 0.101
0.531 ± 0.074
Values are expressed as mean ± SD for five rats in each group. Groups: control (0 mg⋅kg−1) group, 4 mg⋅kg−1 GM group, 20 mg⋅kg−1 GM group, and 100 mg⋅kg−1 GM group.
