The Impact of Biopsy on Human Embryo Developmental Potential during Preimplantation Genetic Diagnosis

Figure 1

Oocyte first polar body biopsy prior to fertilization displayed through polarized light microscopy. Polarized light microscopy allows identification of the chromosome meiotic spindle (indicated by the white arrows in all figures). (a)–(d) Metaphase II oocyte first polar body biopsy with no damage to the meiotic spindle; ()–() Telophase I oocyte first polar body biopsy with enucleation of the oocyte whose meiotic spindle remains attached to the polar body during aspiration.