BioMed Research International / 2016 / Article / Tab 4

Research Article

Identification and Evolutionary Analysis of Potential Candidate Genes in a Human Eating Disorder

Table 4

Tests of overall positive selection of VGF protein using CODEML of PAML.

Modelln LParameter estimates−2Δln LPositively selected sites

M0 (one-ratio)−22230.135

M3 (discrete)−21925.088 = 0.308; = 0.031 
= 0.580; = 0.272 
= 0.112; = 0.763
n.s.

M1a (neutral)−22088.358 = 0.870; = 0.184 
= 0.131; = 1.000

M2a (selection)−22088.358 = 0.869; = 0.184 
= 0.089; = 1.000 
= 0.042; = 1.000
n.s.

M7 (beta)−22007.790 = 0.843, = 2.462

M8 (beta&ω > 1)−22005.004 = 0.976; = 0.955 
= 3.090; = 0.024; = 1.054
n.s.499, 501, 512, 576, and 579; 
442, 505, and 518

log-likelihood; likelihood ratio test (LRT) for detection of positive selection; sites inferred to be under positive selection pressure posterior probability by BEB method; sites inferred to be under positive selection pressure posterior probability by NEB method; not significant.

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