Identification and Evolutionary Analysis of Potential Candidate Genes in a Human Eating Disorder

Table 5

Evaluation of McDonald-Kreitman 2 × 2 contingency table by Fisher’s Exact Test (FET).

		Nonsynonymous	Synonymous	Total
VGF
	Within species variation	27	16	43
	Fixed species differences	79	146	225
	Total	106	162	268
Calr
	Within species variation	30	24	54
	Fixed species differences	5	39	44
	Total	35	63	98
Htra1
	Within species variation	19	22	41
	Fixed species differences	45	163	208
	Total	64	185	249
Manf
	Within species variation	7	2	9
	Fixed species differences	5	39	44
	Total	12	41	53

All known mutations within humans; differences when comparing human gene to mouse; only those polymorphisms identified by dbSNP as either synonymous or missense (nonsynonymous) are considered in this table. values less than 0.05 are considered significant.