BioMed Research International / 2016 / Article / Tab 1

Review Article

Gray Matter Atrophy within the Default Mode Network of Fibromyalgia: A Meta-Analysis of Voxel-Based Morphometry Studies

Table 1

Overview of the fibromyalgia VBM studies in this meta-analysis.

NameYearJournal Sample/female Mean age ± SDSymptoms duration (years)Foci numberMain area of fociScannerStatistical thresholdSmoothing kernel (mm)GM changeTal or MNI
CaseControlCaseControl

Kuchinad2007J. Neurosci10/1010/1052455Cingulate, insular, medial frontal cortices, parahippocampal gyriSiemens 1.5 T corrected10Tal
Schmidt- Wilcke2007J. Pain20/1922/206GM decrease in superior temporal gyrus and post. thalamus; GM increase in OFC, cerebellum, striatumSiemens 1.5 T corrected10↑↓Tal
Wood2009J. Pain30/3020/20NA4GM decrease in PCC, ACC, parahippocampal gyriGE 1.5 T uncorr.12Tal
Hsu2009J. Pain29/2929/290No changeGE 3 T corrected10N/AMNI
Fallon2013Neuroimage Clin.16/1615/154GM decrease in pons, precuneus; GM increase in SISiemens 3 T corrected10↑↓MNI
Ceko2013Neuroimage Clin.14/1413/1314GM decrease in bilateral ACC, MPFC, frontal pole, right premotor cortex, VLPFC, right DLPFC, right PCCSiemens 3 T corrected8MNI
Ceko2013Neuroimage Clin.14/1415/159GM increase in right VLPFC, putamen/GP/NAc, left insula, putamenSiemens 3 T corrected8MNI
Diaz-Piedra2015Brain Imaging Behav23/2323/232GM decrease in l’ Frontal Med/Sup Orb; GM increase in l’ Temporal PolePhillips 3 T corrected8↑↓MNI

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