Review Article
Gray Matter Atrophy within the Default Mode Network of Fibromyalgia: A Meta-Analysis of Voxel-Based Morphometry Studies
Table 1
Overview of the fibromyalgia VBM studies in this meta-analysis.
| | Name | Year | Journal | Sample/female | Mean age ± SD | Symptoms duration (years) | Foci number | Main area of foci | Scanner | Statistical threshold | Smoothing kernel (mm) | GM change | Tal or MNI | | Case | Control | Case | Control |
| | Kuchinad | 2007 | J. Neurosci | 10/10 | 10/10 | 52 | 45 | | 5 | Cingulate, insular, medial frontal cortices, parahippocampal gyri | Siemens 1.5 T | corrected | 10 | ↓ | Tal | | Schmidt- Wilcke | 2007 | J. Pain | 20/19 | 22/20 | | | | 6 | GM decrease in superior temporal gyrus and post. thalamus; GM increase in OFC, cerebellum, striatum | Siemens 1.5 T | corrected | 10 | ↑↓ | Tal | | Wood | 2009 | J. Pain | 30/30 | 20/20 | | | NA | 4 | GM decrease in PCC, ACC, parahippocampal gyri | GE 1.5 T | uncorr. | 12 | ↓ | Tal | | Hsu | 2009 | J. Pain | 29/29 | 29/29 | | | | 0 | No change | GE 3 T | corrected | 10 | N/A | MNI | | Fallon | 2013 | Neuroimage Clin. | 16/16 | 15/15 | | | | 4 | GM decrease in pons, precuneus; GM increase in SI | Siemens 3 T | corrected | 10 | ↑↓ | MNI | | Ceko | 2013 | Neuroimage Clin. | 14/14 | 13/13 | | | | 14 | GM decrease in bilateral ACC, MPFC, frontal pole, right premotor cortex, VLPFC, right DLPFC, right PCC | Siemens 3 T | corrected | 8 | ↓ | MNI | | Ceko | 2013 | Neuroimage Clin. | 14/14 | 15/15 | | | | 9 | GM increase in right VLPFC, putamen/GP/NAc, left insula, putamen | Siemens 3 T | corrected | 8 | ↑ | MNI | | Diaz-Piedra | 2015 | Brain Imaging Behav | 23/23 | 23/23 | | | | 2 | GM decrease in l’ Frontal Med/Sup Orb; GM increase in l’ Temporal Pole | Phillips 3 T | corrected | 8 | ↑↓ | MNI |
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