NALP3-Inflammasome-Related Gene Polymorphisms in Patients with Prehypertension and Coronary Atherosclerosis
Table 3
Genotypes and allele frequencies of the NOD2 gene SNP polymorphisms among prehypertensive patients.
Genotype SNPs
Allele
Genotype (stenosis < 50%)
Genotype (stenosis ≥ 50%)
Allele A versus B
AA versus BB
BB versus AB
A
B
AA (%)
AB (%)
BB (%)
AA (%)
AB (%)
BB (%)
OR (95% CI)
value
Bonf-p
OR (95% CI)
value
Bonf-p
OR (95% CI)
value
Bonf-p
rs1077861
A
T
197 (70.11)
77 (27.40)
7 (2.49)
185 (62.71)
94 (31.86)
16 (5.42)
2.769
1.367 (0.945–1.976)
0.096
1.000
1.449 (0.835–2.513)
0.187
1.000
0.8981 (0.4619–1.746)
0.187
1.000
rs1861759
A
C
221 (78.65)
57 (20.28)
3 (1.07)
208 (70.51)
80 (27.12)
7 (2.37)
3.247
1.477 (0.965–2.260)
0.072
1.000
1.461 (0.620–3.44)
0.386
1.000
1.026 (0.395–2.667)
0.957
1.000
rs2067085
C
G
249 (88.61)
32 (11.39)
0 (0)
257 (87.12)
32 (10.85)
6 (2.03)
0.956
1.335 (0.747–2.386)
0.328
1.000
<0.001
0.999
1.000
<0.001
0.999
1.000
rs2111235
T
C
154 (54.80)
107 (38.08)
20 (7.12)
116 (39.32)
147 (49.83)
32 (10.85)
8.15
1.576 (1.152–2.155)
0.004
0.006
1.458 (1–2.125)
0.049
0.735
1.256 (0.771–2.044)
0.360
1.000
rs3135499
A
C
176 (62.63)
89 (31.67)
16 (5.69)
160 (54.24)
112 (37.97)
23 (7.80)
2.506
1.310 (0.937–1.832)
0.113
1.000
1.222 (0.810–1.843)
0.339
1.000
1.128 (0.660–1.929)
0.660
1.000
rs4785225
C
G
173 (61.57)
91 (32.38)
17 (6.05)
160 (54.24)
110 (37.29)
25 (8.47)
2.345
1.298 (0.929–1.812)
0.126
1.000
1.251 (0.834–1.878)
0.280
1.000
1.05 (0.616–1.788)
0.858
1.000
rs7205423
C
G
168 (59.79)
95 (33.81)
18 (6.41)
130 (44.07)
135 (45.76)
30 (10.17)
8.885
1.627 (1.180–2.243)
0.003
0.045
1.469 (1–2.158)
0.050
0.750
1.251 (0.756–2.07)
0.576
1.000
rs751271
A
C
174 (61.92)
89 (31.67)
18 (6.41)
157 (53.22)
114 (38.64)
24 (8.14)
2.824
1.328 (0.953–1.850)
0.093
1.000
1.215 (0.817–1.807)
0.337
1.000
1.178 (0.697–1.991)
0.540
1.000
rs8056611
A
G
153 (54.45)
106 (37.72)
22 (7.83)
119 (40.34)
142 (48.14)
34 (11.53)
7.083
1.526 (1.117–2.085)
0.008
0.120
1.419 (0.984–2.047)
0.061
0.915
1.217 (0.753–1.969)
0.423
1.000
SNP: single nucleotide polymorphism; CI: confidence interval; OR: odds ratio. Bonf-p: value with Bonferroni correction. Allele A is the wild-type allele.
