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BioMed Research International
Volume 2016 (2016), Article ID 7486425, 10 pages
http://dx.doi.org/10.1155/2016/7486425
Research Article

Identification of Novel RD1 Antigens and Their Combinations for Diagnosis of Sputum Smear−/Culture+ TB Patients

1Department of Bio-Diagnosis, Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Haidian District, Beijing 100850, China
2Institute for Medical Devices Control, National Institute for Food and Drug Control, No. 2 Tiantan Xili, Chongwen District, Beijing 100050, China
3Chaoyang District Centre for Disease Control and Prevention, 25 Panjiayuan Huaweili, Beijing 100029, China
4Olympia Diagnostics, Inc., 640 W. California Avenue, Sunnyvale, CA 94086, USA

Received 22 July 2015; Revised 30 September 2015; Accepted 4 November 2015

Academic Editor: Aparup Das

Copyright © 2016 Zhiqiang Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. L. Flores, K. R. Steingart, N. Dendukuri et al., “Systematic review and meta-analysis of antigen detection tests for the diagnosis of tuberculosis,” Clinical and Vaccine Immunology, vol. 18, no. 10, pp. 1616–1627, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Alavi-Naini, L. E. Cuevas, S. B. Squire, M. Mohammadi, and A.-A. Davoudikia, “Clinical and laboratory diagnosis of the patients with sputum smear-negative pulmonary tuberculosis,” Archives of Iranian Medicine, vol. 15, no. 1, pp. 22–26, 2012. View at Google Scholar · View at Scopus
  3. S. Gounder, K. Tayler-Smith, M. Khogali, M. Raikabula, and A. D. Harries, “Audit of the practice of sputum smear examination for patients with suspected pulmonary tuberculosis in Fiji,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 107, no. 7, pp. 427–431, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Grandjean, L. Martin, R. H. Gilman et al., “Tuberculosis diagnosis and multidrug resistance testing by direct sputum culture in selective broth without decontamination or centrifugation,” Journal of Clinical Microbiology, vol. 46, no. 7, pp. 2339–2344, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. American Thoracic Society, “Targeted tuberculin testing and treatment of latent tuberculosis infection,” MMWR Recommendations and Reports, vol. 49, no. RR-6, pp. 1–51, 2000. View at Google Scholar
  6. A. M. Alnimr and M. I. Hassan, “Potential of two nucleic acid amplification assays for quantifying mycobacterial load in respiratory and non-respiratory specimens: a prospective study,” Diagnostic Microbiology and Infectious Disease, vol. 78, no. 3, pp. 237–241, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Pai, “Diagnosis of pulmonary tuberculosis: recent advances,” Journal of the Indian Medical Association, vol. 111, no. 5, pp. 332–336, 2013. View at Google Scholar · View at Scopus
  8. R. E. Huebner, M. F. Schein, and J. B. Bass Jr., “The tuberculin skin test,” Clinical Infectious Diseases, vol. 17, no. 6, pp. 968–975, 1993. View at Publisher · View at Google Scholar · View at Scopus
  9. X. Zhang, J. Guo, S. Fan et al., “Screening and identification of six serum microRNAs as novel potential combination biomarkers for pulmonary tuberculosis diagnosis,” PLoS ONE, vol. 8, no. 12, Article ID e81076, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. B. C. Harinath, S. Kumar, S. S. Roy, S. Hirudkar, V. Upadhye, and N. Shende, “A cocktail of affinity-purified antibodies reactive with diagnostically useful mycobacterial antigens ES-31, ES-43, and EST-6 for detecting the presence of Mycobacterium tuberculosis,” Diagnostic Microbiology and Infectious Disease, vol. 55, no. 1, pp. 65–68, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Qi, L. Cui, Y. Ge et al., “Altered serum microRNAs as biomarkers for the early diagnosis of pulmonary tuberculosis infection,” BMC Infectious Diseases, vol. 12, article 384, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Kalra, G. K. Khuller, A. Grover, D. Behera, A. Wanchu, and I. Verma, “Utility of a combination of RD1 and RD2 antigens as a diagnostic marker for tuberculosis,” Diagnostic Microbiology and Infectious Disease, vol. 66, no. 2, pp. 153–161, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Raju, S. Suneetha, K. Sagili et al., “Diagnostic role of the antibody response to the 38kDa, 16kDa proteins and lipoarabinomannan of mycobacterium tuberculosis,” Indian Journal of Clinical Biochemistry, vol. 20, no. 1, pp. 123–128, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. X.-L. Tang, Y.-X. Zhou, S.-M. Wu, Q. Pan, B. Xia, and X.-L. Zhang, “CFP10 and ESAT6 aptamers as effective Mycobacterial antigen diagnostic reagents,” Journal of Infection, vol. 69, no. 6, pp. 569–580, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Majumdar, P. D. Kamble, and B. C. Harinath, “Detection of circulating free and immune-complexed antigen in pulmonary tuberculosis using cocktail of antibodies to mycobacterium tuberculosis excretory secretory antigens by peroxidase enzyme immunoassay,” Indian Journal of Tuberculosis, vol. 57, no. 2, pp. 67–74, 2010. View at Google Scholar · View at Scopus
  16. A. Azzurri, G. V. Kanaujia, O. Y. Sow et al., “Serological markers of pulmonary tuberculosis and of response to anti-tuberculosis treatment in a patient population in Guinea,” International Journal of Immunopathology and Pharmacology, vol. 19, no. 1, pp. 199–208, 2006. View at Google Scholar · View at Scopus
  17. X. Feng, B. Xiu, K. Chen et al., “Enhanced serodiagnostic utility of novel Mycobacterium tuberculosis polyproteins,” Journal of Infection, vol. 66, no. 4, pp. 366–375, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Deng, T. Yuan, J. Xia, H. Huang, X. Cheng, and M. Chen, “Clinical utility of a combination of lipoarabinomannan, 38-kDa, and 16-kDa antigens as a diagnosis tool for tuberculosis,” Diagnostic Microbiology and Infectious Disease, vol. 71, no. 1, pp. 46–50, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. X. Y. He, J. Li, J. Hao et al., “Assessment of five antigens from Mycobacterium tuberculosis for serodiagnosis of tuberculosis,” Clinical and Vaccine Immunology, vol. 18, no. 4, pp. 565–570, 2011. View at Publisher · View at Google Scholar
  20. J. Chen, X. Su, Y. Zhang et al., “Novel recombinant RD2- and RD11-encoded Mycobacterium tuberculosis antigens are potential candidates for diagnosis of tuberculosis infections in BCG-vaccinated individuals,” Microbes and Infection, vol. 11, no. 10-11, pp. 876–885, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. X. Feng, X. Yang, B. Xiu et al., “IgG, IgM and IgA antibodies against the novel polyprotein in active tuberculosis,” BMC Infectious Diseases, vol. 14, no. 1, article 336, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. Y.-Q. Qiu, Y.-X. Tang, and J. He, “Diagnostic P300 threshold based on the analysis of receiver operating characteristic curve,” Zhonghua Yi Xue Za Zhi, vol. 93, no. 41, pp. 3261–3264, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Liu, W.-J. Zhang, J. Zheng et al., “Exploration of novel cellular and serological antigen biomarkers in the orfeome of Mycobacterium tuberculosis,” Molecular and Cellular Proteomics, vol. 13, no. 3, pp. 897–906, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. P. Aggarwal and D. Aggarwal, “Serological test for tuberculosis: so near yet so far,” Journal of Infection, vol. 67, no. 3, pp. 241–242, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. D. W. Dowdy, K. R. Steingart, and M. Pai, “Serological testing versus other strategies for diagnosis of active tuberculosis in india: a cost-effectiveness analysis,” PLoS Medicine, vol. 8, no. 8, Article ID e1001074, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. X.-X. Li, S.-W. Jaing, H. Zhang et al., “Clinical and radiographic predictors in diagnosing sputum smear-negative pulmonary tuberculosis in HIV-negative patients: a cross-sectional study in China,” Chinese Medical Journal, vol. 126, no. 19, pp. 3662–3667, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. H. F. Swai, F. M. Mugusi, and J. K. Mbwambo, “Sputum smear negative pulmonary tuberculosis: sensitivity and specificity of diagnostic algorithm,” BMC Research Notes, vol. 4, article 475, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. J. He, B. Xiu, G. Wang et al., “Construction, expression, purification and biotin labeling of a single recombinant multi-epitope antigen for double-antigen sandwich ELISA to detect hepatitis C Virus antibody,” Protein and Peptide Letters, vol. 18, no. 8, pp. 839–847, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. T. Tanimura, E. Jaramillo, D. Weil, M. Raviglione, and K. Lönnroth, “Financial burden for tuberculosis patients in low- and middle-income countries: a systematic review,” European Respiratory Journal, vol. 43, no. 6, pp. 1763–1775, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. P. Molicotti, A. Bua, and S. Zanetti, “Cost-effectiveness in the diagnosis of tuberculosis: choices in developing countries,” Journal of Infection in Developing Countries, vol. 8, no. 1, pp. 24–38, 2014. View at Publisher · View at Google Scholar · View at Scopus
  31. M. O. C. Ota, J. F. Mendy, S. Donkor et al., “Rapid diagnosis of tuberculosis using ex vivo host biomarkers in sputum,” European Respiratory Journal, vol. 44, no. 1, pp. 254–257, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. M. A. Chambers, K. P. Lyashchenko, R. Greenwald et al., “Evaluation of a rapid serological test for the determination of Mycobacterium bovis infection in badgers (Meles meles) found dead,” Clinical and Vaccine Immunology, vol. 17, no. 3, pp. 408–411, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. C. M. Castro, T. B. Porras, M. I. Guerrero et al., “Development of a multiantigenic serological test for tuberculosis diagnosis,” Biomédica, vol. 25, no. 1, pp. 55–64, 2005. View at Google Scholar · View at Scopus
  34. X. Wu, Y. Yang, J. Zhang et al., “Comparison of antibody responses to seventeen antigens from Mycobacterium tuberculosis,” Clinica Chimica Acta, vol. 411, no. 19-20, pp. 1520–1528, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. J. Chen, S. Wang, Y. Zhang et al., “Rv1985c, a promising novel antigen for diagnosis of tuberculosis infection from BCG-vaccinated controls,” BMC Infectious Diseases, vol. 10, article 273, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Shah and C. Reed, “Complications of tuberculosis,” Current Opinion in Infectious Diseases, vol. 27, no. 5, pp. 403–410, 2014. View at Publisher · View at Google Scholar
  37. D. Wilson, L. Mbhele, M. Badri et al., “Evaluation of the World Health Organization algorithm for the diagnosis of HIV-associated sputum smear-negative tuberculosis,” International Journal of Tuberculosis and Lung Disease, vol. 15, no. 7, pp. 919–924, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. J. Ivanyi, “Serodiagnosis of tuberculosis: due to shift track,” Tuberculosis, vol. 92, no. 1, pp. 31–37, 2012. View at Publisher · View at Google Scholar · View at Scopus