Identification of Novel RD1 Antigens and Their Combinations for Diagnosis of Sputum Smear−/Culture+ TB Patients

Table 1

Diagnostic performance of individual antigens.

Antigens		Rv3871		Rv3874		Rv3875		Rv3876		Rv3879
		+	−	+	−	+	−	+	−	+	−
TB	298	242	56	188	110	96	102	186	112	249	49
Control	95	24	71	5	90	12	83	14	81	16	79
Sensitivity		81.21%		63.09%		32.21%		62.42%		83.56%
Specificity		74.74%		94.74%		87.37%		85.26%		83.16%
Youden		0.5595		0.5783		0.1958		0.4768		0.6672
PPV		90.98%		97.41%		88.89%		93.0%		93.96%
NPV		55.91%		45%		44.86%		41.97%		61.72%

PPV: positive predictive value, NPV: negative predictive value, and Youden: Youden index = sensitivity + specificity – 1.