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BioMed Research International
Volume 2016, Article ID 7496061, 10 pages
Research Article

Analyzing Dynamic Changes of Laboratory Indexes in Patients with Acute Heart Failure Based on Retrospective Study

1Core Laboratory of Translational Medicine, Chinese PLA General Hospital, Beijing 100853, China
2School of Medicine, Nankai University, Tianjin 300071, China
3Department of Medical Engineering, 401 Hospital of Chinese PLA, Qingdao 266071, China
4Computer Section of Chinese PLA General Hospital, Beijing 100853, China
5Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China

Received 5 January 2016; Revised 9 March 2016; Accepted 20 March 2016

Academic Editor: Laurent Metzinger

Copyright © 2016 Yurong Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Changes of N-terminal probrain natriuretic peptide (NT-proBNP) have been studied whether in the long term or the short term in patients of acute heart failure (AHF); however, changes of NT-proBNP in the first five days and their association with other factors have not been investigated. Aims. To describe the dynamic changes of relevant laboratory indexes in the first five days between different outcomes of AHF patients and their associations. Methods and Results. 284 AHF with dynamic values recorded were analyzed. Changes of NT-proBNP, troponin T, and C-reactive protein were different between patients with different outcomes, with higher values in adverse group than in control group at the same time points (). Then, prognostic use and risk stratification of NT-proBNP were assessed by receiver-operating characteristic curve and logistic regression. NT-proBNP levels at day 3 showed the best prognostic power (area under the curve = 0.730, 95% confidence interval (CI): 0.657 to 0.794) and was an independent risk factor for adverse outcome (odds ratio, OR: 2.185, 95% CI: 1.584–3.015). Classified changes of NT-proBNP may be predictive for adverse outcomes in AHF patients. Conclusions. Sequential monitoring of laboratory indexes within the first 5 days may be helpful for management of AHF patients.