BioMed Research International / 2016 / Article / Fig 1

Research Article

Lamotrigine Reduces Inflammatory Response and Ameliorates Executive Function Deterioration in an Alzheimer’s-Like Mouse Model

Figure 1

APP/PS1 mice (9 months old) showed plaque deposition, astrocyte activation, and higher level of IL-6 and IL-1β production in the brains. (a) Representative photograph of plaque deposition (Congo Red) in 9-month-old APP/PS1 mice (left); representative photograph of costaining of GFAP and Congo Red in 9-month-old APP/PS1 mice (right). Scale bar represents 500 μm. (b) Western blot analysis showed an increase of GFAP expression in APP/PS1 mouse brain cortex (). . (c) Western blot analysis showed an increase of IL-1β in APP/PS1 mouse brain cortex (). . (d) IL-6 was measured with ELISA kit in the brain tissue of cortical area of WT and APP/PS1 mice (). . (e) IL-1 β was measured with ELISA kit in the brain tissue of cortical area of WT and APP/PS1 mice (). . All data are expressed as means ± SEM.
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