Adult Onset Vitiligo: Multivariate Analysis Suggests the Need for a Thyroid Screening
Table 1
Patients characteristics and complete results of the univariate analysis.
Parameter ()
Age of onset <12 years
Age of onset >40 years
OR
Mean age at onset
7 years (range 0–12)
50.25 years (range 40–83)
Mean age at time of consultation
19.5 years (range 3–69)
56.3 years (range 41–85)
Mean duration of the disease
12.2 years (range 0.3–62)
6.2 years (range 0.2–30)
Sex
Female
34 (50.0%)
68 (55.2%)
0.438
1.236
Male
34 (50.0%)
55 (44.8%)
Type
Segmental
4 (5.9%)
4 (3.3%)
0.463
0.552
Nonsegmental
62 (91.2%)
116 (96.6%)
0.173
2.806
Unclassified
2 (2.9%)
0
0.130
0.355
Family history
Vitiligo
22 (32.3%)
25 (24.3%)
0.247
0.670
Psoriasis
17 (25.0%)
15 (14.5%)
0.087
0.511
Melanoma
4 (5.8%)
6 (5.8%)
0.988
0.990
Dermatological
36 (52.9%)
37 (34.2%)
0.002
2.615
Thyroid disease
23 (33.8%)
29 (26.8%)
0.324
0.718
Cardiovascular disease
9 (13.2%)
10 (10.0%)
0.516
0.728
Type I diabetes
1 (1.4%)
5 (4.9%)
0.231
3.490
Type II diabetes
12 (17.6%)
16 (15.8%)
0.921
0.878
Autoimmune disease
8 (11.7%)
4 (4.0%)
0.020
3.96
Hypertension
14 (20.5%)
13 (12.8%)
0.179
0.570
Neurologic disease
0 (0.0%)
1 (1.0%)
0.406
0.590
Personal history of
Thyroid disease
13 (19.1%)
40 (37.7%)
<0.001
0.27
ATD
7 (10.6%)
27 (25.0%)
0.020
0.22
Thyroid nodules
0%
13 (12.0%)
0.002
0.90
Cardiovascular disease
3 (4.4%)
5 (5.0%)
1.000
1.152
Autoimmune disease
3 (4.4%)
7 (7.0%)
0.742
1.649
Type I diabetes
0 (0.0%)
2 (2.0%)
0.515
0.590
Type II diabetes
0 (0.0%)
3 (3.0%)
0.273
0.588
Hypertension
0 (0.0%)
18 (18.1%)
<0.001
0.8
Psychiatric disease
0 (0.0%)
3 (3.0%)
0.273
0.588
Neurologic disease
1 (1.5%)
2 (2.0%)
1.000
1.367
Phototype
I
1 (1.5%)
0 (0.0%)
0.364
0.360
II
36 (52.9%)
44 (36.9%)
0.034
0.521
III
28 (41.2%)
68 (62.4%)
0.036
1.905
IV
2 (2.9%)
7 (5.9%)
0.491
2.063
V
1 (1.5%)
0 (0.0%)
0.364
0.360
Previous episode of repigmentation
Spontaneous
4 (5.9%)
8 (8.0%)
0.764
1.376
Drug induced
27 (39.7%)
33 (32.9%)
0.349
0.737
Photoexposition
9 (13.2%)
9 (9.0%)
0.372
0.641
Type of Onset
Sudden
30 (44.1%)
57 (48.7%)
0.618
1.165
Progressive
35 (51.5%)
62 (52.1%)
0.934
1.026
Leucotrichia
16 (23.5%)
35 (36.0%)
0.086
1.835
Sutton
8 (11.7%)
7 (8.9%)
0.580
0.739
Koebner
42 (61.7%)
43 (43.8%)
<0.001
0.484
Stress as onset factor
29 (42.6%)
67 (65.0%)
<0.001
2.503
Continuous variables such as age, age of onset, and vitiligo duration are reported as mean ± SD and expressed in years. For every other parameter evaluated, we report the number and the percentage of patients positive or negative for that parameter.