Research Article

Adult Onset Vitiligo: Multivariate Analysis Suggests the Need for a Thyroid Screening

Table 1

Patients characteristics and complete results of the univariate analysis.

Parameter ()Age of onset <12 yearsAge of onset >40 yearsOR

Mean age at onset 7 years (range 0–12)50.25 years (range 40–83)

Mean age at time of consultation 19.5 years (range 3–69)56.3 years (range 41–85)

Mean duration of the disease 12.2 years (range 0.3–62)6.2 years (range 0.2–30)

Sex
 Female34 (50.0%)68 (55.2%)0.4381.236
 Male34 (50.0%)55 (44.8%)

Type
 Segmental4 (5.9%)4 (3.3%)0.4630.552
 Nonsegmental62 (91.2%)116 (96.6%)0.1732.806
 Unclassified2 (2.9%)00.1300.355

Family history
 Vitiligo 22 (32.3%)25 (24.3%)0.2470.670
 Psoriasis 17 (25.0%)15 (14.5%)0.0870.511
 Melanoma 4 (5.8%)6 (5.8%)0.9880.990
 Dermatological36 (52.9%)37 (34.2%)0.0022.615
 Thyroid disease 23 (33.8%)29 (26.8%)0.3240.718
 Cardiovascular disease9 (13.2%)10 (10.0%)0.5160.728
 Type I diabetes 1 (1.4%)5 (4.9%)0.2313.490
 Type II diabetes 12 (17.6%)16 (15.8%)0.9210.878
 Autoimmune disease8 (11.7%)4 (4.0%)0.0203.96
 Hypertension 14 (20.5%)13 (12.8%)0.1790.570
 Neurologic disease 0 (0.0%)1 (1.0%)0.4060.590

Personal history of
 Thyroid disease13 (19.1%)40 (37.7%)<0.0010.27
 ATD 7 (10.6%)27 (25.0%)0.0200.22
 Thyroid nodules 0%13 (12.0%)0.0020.90
 Cardiovascular disease 3 (4.4%)5 (5.0%)1.0001.152
 Autoimmune disease 3 (4.4%)7 (7.0%)0.7421.649
 Type I diabetes 0 (0.0%)2 (2.0%)0.5150.590
 Type II diabetes 0 (0.0%)3 (3.0%)0.2730.588
 Hypertension0 (0.0%)18 (18.1%)<0.0010.8
 Psychiatric disease 0 (0.0%)3 (3.0%)0.2730.588
 Neurologic disease 1 (1.5%)2 (2.0%)1.0001.367

Phototype
 I1 (1.5%)0 (0.0%)0.3640.360
 II36 (52.9%)44 (36.9%)0.0340.521
 III28 (41.2%)68 (62.4%)0.0361.905
 IV2 (2.9%)7 (5.9%)0.4912.063
 V1 (1.5%)0 (0.0%)0.3640.360

Previous episode of repigmentation
 Spontaneous4 (5.9%)8 (8.0%)0.7641.376
 Drug induced 27 (39.7%)33 (32.9%)0.3490.737
 Photoexposition9 (13.2%)9 (9.0%)0.3720.641

Type of Onset
 Sudden30 (44.1%)57 (48.7%)0.6181.165
 Progressive35 (51.5%)62 (52.1%)0.9341.026

Leucotrichia 16 (23.5%)35 (36.0%)0.0861.835

Sutton8 (11.7%)7 (8.9%)0.5800.739

Koebner42 (61.7%)43 (43.8%)<0.0010.484

Stress as onset factor29 (42.6%)67 (65.0%)<0.0012.503

Continuous variables such as age, age of onset, and vitiligo duration are reported as mean ± SD and expressed in years. For every other parameter evaluated, we report the number and the percentage of patients positive or negative for that parameter.