Relation between Age-Related Macular Degeneration and Cardiovascular Events and Mortality: A Systematic Review and Meta-Analysis

Table 2

Stratified analyses of stroke associated with AMD.

Group	Number of studies	RR (95% CI)	(heterogeneity)	(%)
Total	8	1.13 [0.93, 1.36]	<0.00001	92
Length of follow-up (years)
<5	3	0.88 [0.64, 1.20]	<0.00001	97
≥5	5	1.40 [1.05, 1.87]	0.002	76
Number of participants
<10000	3	1.27 [0.86, 1.87]	0.009	79
≥10000	5	1.07 [0.83, 1.38]	<0.00001	95
Type
Early AMD	5	1.21 [1.03, 1.42]	0.007	71
Late AMD	6	1.14 [0.85, 1.52]	<0.00001	95
Study design
Prospective	4	1.07 [0.90, 1.26]	0.03	66
Retrospective	4	1.22 [0.75, 1.99]	<0.00001	95