Research Article

Next Generation Sequencing Identifies Five Major Classes of Potentially Therapeutic Enzymes Secreted by Lucilia sericata Medical Maggots

Table 5

List of metallopeptidases in the L. sericata transcriptome database.

ClanFamilyPeptidase typePeptidase speciesMEROPS IDNumber of clusters

MAM1 Aminopeptidase N ERAP2 aminopeptidaseM01.0245
Slamdance (D. melanogaster)M01.A022
CG5845 protein (D. melanogaster)M01.A051
CG11956 protein (D. melanogaster)M01.A096
Dgri protein (D. melanogaster)M01.A102
CG8774 protein (D. melanogaster)M01.A113
CG8773 protein (D. melanogaster)M01.A121
AT4g33090 g.p. (Arabidopsis thaliana)M01.A256
Family M1 nonpeptidase homologuesM01.UNW3
Family M1 unassigned peptidasesM01.UPW4

MAM2 Angiotensin-converting enzyme peptidase unit 1 Peptidyl-dipeptidase AnceM02.00316
Family M2 nonpeptidase homologuesM02.UNW6
Family M2 unassigned peptidasesM02.UPW4

MAM3 Thimet oligopeptidase Subfamily M3A nonpeptidase homologuesM03.UNA1
Subfamily M3A unassigned peptidasesM03.UPA1

MAM8LeishmanolysinFamily M8 unassigned peptidasesM08.UPW2

MAM10 Matrix metallopeptidase-1 Dm1 matrix metallopeptidaseM10.0312
Dm2-matrix metallopeptidaseM10.0362

MAM12 Astacin Mammalian-type tolloid-like 2 proteinM12.0181
ADM-4 peptidase (Caenorhabditis elegans)M12.3291
ADAMTS-A (D. melanogaster)M12.A031
CG4096 protein (D. melanogaster)M12.A042
CG4096 protein (D. melanogaster)M12.A051
CG6696 protein (D. melanogaster)M12.A081
CG15254 protein (D. melanogaster)M12.A091
Subfamily M12A unassigned peptidasesM12.UPA10
Subfamily M12B unassigned peptidasesM12.UPB8

MAM13 Neprilysin Zmp1 peptidase (Mycobacterium-type)M13.0092
Nep2 peptidase (insect)M13.0122
Neprilysin-4 (D. melanogaster)M13.0142
CG3775 protein (D. melanogaster)M13.A012
CG14526 protein (D. melanogaster)M13.A042
CG14528 protein (D. melanogaster)M13.A061
CG9507 protein (D. melanogaster)M13.A112
CG5894 protein (D. melanogaster)M13.A152
Family M13 nonpeptidase homologuesM13.UNW6
Family M13 unassigned peptidasesM13.UPW13

MAM41 FtsH peptidase ParapleginM41.0061
YME1L1 g.p. (Homo sapiens) and similarM41.0261
Family M41 nonpeptidase homologuesM41.UNW1

MAM48Ste24 peptidaseCG9001 protein (D. melanogaster)M48.A062

MAM49Dipeptidyl-peptidase IIICG7415 g.p. (D. melanogaster)M49.A012

MCM14 Carboxypeptidase A1 CG8560 protein (D. melanogaster)M14.A042
CG2915 protein (D. melanogaster)M14.A056
CG17633 protein (D. melanogaster)M14.A081
CG14820 protein (D. melanogaster)M14.A122
CG8562 protein (D. melanogaster)M14.A151
CG18417 protein (D. melanogaster)M14.A161
CG3097 protein (D. melanogaster)M14.A191
Silver protein domain 2 (D. melanogaster)M14.A202
CG11428 (D. melanogaster)M14.A212
Subfamily M14A nonpeptidase homologuesM14.UNA1
Subfamily M14A unassigned peptidasesM14.UPA11
Subfamily M14B unassigned peptidasesM14.UPB3

MEM16 Pitrilysin Mitochondrial processing peptidase beta-subunitM16.0031
EupitrilysinM16.0091
Mername-AA224 nonpeptidase homologueM16.9752
CG2025 protein (D. melanogaster)M16.A063
C02G6.1 g.p. (C. elegans)M16.A081
LOC133083 g.p. (H. sapiens)M16.P012

MFM17 Leucine aminopeptidase 3 Leucyl aminopeptidase-1 (Caenorhabditis-type)M17.0062
Leucine aminopeptidase (Fasciola-type)M17.0112

MGM24 Methionyl aminopeptidase 1 Xaa-Pro dipeptidase (eukaryote)M24.0072
Methionyl aminopeptidase 1 (eukaryote)M24.0171
Subfamily M24B nonpeptidase homologuesM24.UNB1
Family M24 nonpeptidase homologuesM24.UNW1
Subfamily M24A unassigned peptidasesM24.UPA2
Subfamily M24B unassigned peptidasesM24.UPB2

MH M20Glutamate carboxypeptidasePeptidase TM20.0031

ā€ƒM28 Aminopeptidase S Aminopeptidase ES-62 (Acanthocheilonema viteae)M28.A151
Family M28 unassigned peptidasesM28.UPW6

MJM19Membrane dipeptidaseFamily M19 nonpeptidase homologuesM19.UNW1

MMM50Site 2 peptidasedS2P peptidase (D. melanogaster)M50.0071

MPM67RPN11 peptidaseAt1g71230 (A. thaliana)M67.A021

UNAM79RCE1 peptidaseRCE1 peptidase (H. sapiens-type)M79.0021