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BioMed Research International
Volume 2016, Article ID 8356435, 8 pages
http://dx.doi.org/10.1155/2016/8356435
Research Article

Mutation Detection in an Antibody-Producing Chinese Hamster Ovary Cell Line by Targeted RNA Sequencing

1Biologics & Vaccines, Merck Research Laboratories, Kenilworth, NJ 07033, USA
2Biology & Genetics Informatics, Merck Research Labs IT, Merck & Co, Boston, MA 02115, USA
3Discovery Pharmacogenomics, Merck Research Laboratories, Kenilworth, NJ 07033, USA

Received 18 November 2015; Revised 4 February 2016; Accepted 21 February 2016

Academic Editor: Jorge F. B. Pereira

Copyright © 2016 Siyan Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [3 citations]

The following is the list of published articles that have cited the current article.

  • Dong-Yup Lee, Jong Kwang Hong, Meiyappan Lakshmanan, and Chetan Goudar, “Towards next generation CHO cell line development and engineering by systems approaches,” Current Opinion in Chemical Engineering, vol. 22, pp. 1–10, 2018. View at Publisher · View at Google Scholar
  • Hussain Dahodwala, and Kelvin H Lee, “The fickle CHO: a review of the causes, implications, and potential alleviation of the CHO cell line instability problem,” Current Opinion in Biotechnology, vol. 60, pp. 128–137, 2019. View at Publisher · View at Google Scholar
  • Bhaskar Gollapudi, Shareen H. Doak, Stephen J. Evans, and Martha M. Moore, “Horizon scanning for novel and emerging in vitro mammalian cell mutagenicity test systems,” Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2019. View at Publisher · View at Google Scholar