Mutation Detection in an Antibody-Producing Chinese Hamster Ovary Cell Line by Targeted RNA Sequencing

Figure 6

Four panels correspond to each of the four targets: light chain, heavy chain, GAPDH, and DHFR (clockwise from the top left). Each panel has points for each experimental condition, stratified vertically, exactly as done for the feasibility study (Figure 3). The coloring, jittering, and offsets for the points are also identical to Figure 3, except that there are no spike-in signals here, and hence no blue points. Positions meeting the criteria for significance (-test value <.01) are colored purple.