Association between Polymorphisms in Interleukins 4 and 13 Genes and Chronic Periodontitis in a Han Chinese Population
Table 4
Distributions of rs2070874, rs2243248, and rs1800925 polymorphisms in CP patients and healthy controls.
SNP
Genotype/allele
CP patients (%)
Controls (%)
Crude OR (95% CI)
value
Adjusted OR (95% CI)
P value
rs2070874
T/T
289 (65.7)
210 (64.8)
1
1
C/T
130 (29.5)
96 (29.6)
0.984 (0.716–1.352)
0.935
1.062 (0.266–4.244)
0.933
C/C
21 (4.8)
18 (5.6)
0.848 (0.441–1.631)
0.619
1.082 (0.215–5.460)
0.924
T
708 (80.5)
516 (79.6)
1
1
C
172 (19.5)
132 (20.4)
0.950 (0.737–1.224)
0.698
1.216 (0.455–3.247)
0.696
rs2243248
T/T
401 (91.1)
261 (80.6)
1
1
G/T
38 (8.6)
57 (17.6)
0.434 (0.280–0.673)
0.001
0.276 (0.237–0.322)
0.002
G/G
1 (2.3)
6 (1.8)
0.108 (0.013–0.906)
0.018
0.109 (0.085–0.140)
0.001
T
840 (95.5)
579 (89.4)
1
1
G
40 (4.5)
69 (10.6)
0.400 (0.267–0.598)
0.001
0.321 (0.290–0.355)
0.001
rs1800925
C/C
330 (75.0)
227 (70.1)
1
1
C/T
96 (21.8)
93 (28.7)
0.710 (0.510–0.989)
0.050
0.826 (0.615–1.109)
0.204
T/T
14 (3.2)
4 (1.2)
2.408 (0.782–7.408)
0.145
2.091 (1.230–3.556)
0.301
C
756 (85.9)
547 (84.4)
1
1
T
124 (14.1)
101 (15.6)
0.888 (0.668–1.181)
0.422
1.005 (0.736–1.371)
0.977
Adjusted for gender and age. OR, odds ratio; CI, confidence interval. Significant difference was accepted at . Homozygous genotypes were used as reference group.
