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BioMed Research International
Volume 2016 (2016), Article ID 8406832, 10 pages
Research Article

The Effect of Autologous Platelet Lysate Eye Drops: An In Vivo Confocal Microscopy Study

1Department of Clinical Sciences, Ophthalmology Institute, University of Turin, 10122 Turin, Italy
2Rheumatology Department, AOU Città della Salute e della Scienza di Torino, 10134 Turin, Italy
3Blood Bank, AOU Città della Salute e della Scienza di Torino, 10134 Turin, Italy

Received 13 November 2015; Revised 7 March 2016; Accepted 29 March 2016

Academic Editor: Hong Liang

Copyright © 2016 Antonio M. Fea et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To determine the effectiveness of autologous platelet lysate (APL) eye drops in patients with primary Sjögren syndrome (SS) dry eye, refractory to standard therapy, in comparison with patients treated with artificial tears. We focused on the effect of APL on cornea morphology with the in vivo confocal microscopy (IVCM). Methods. Patients were assigned to two groups: group A used autologous platelet lysate QID, and group B used preservative-free artificial tears QID, for 90 days. Ophthalmological assessments included ocular surface disease index (OSDI), best corrected visual acuity (BCVA), Schirmer test, fluorescein score, and breakup time (BUT). A subgroup of patients in group A underwent IVCM: corneal basal epithelium, subbasal nerves, Langerhans cells, anterior stroma activated keratocytes, and reflectivity were evaluated. Results. 60 eyes of 30 patients were enrolled; in group A ( patients) mean OSDI, fluorescein score, and BUT showed significant improvement compared with group B ( patients). The IVCM showed a significant increase in basal epithelium cells density and subbasal nerve plexus density and number and a decrease in Langerhans cells density (). Conclusion. APL was found effective in the treatment of SS dry eye. IVCM seems to be a useful tool to visualize cornea morphologic modifications.