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BioMed Research International
Volume 2016 (2016), Article ID 8406832, 10 pages
http://dx.doi.org/10.1155/2016/8406832
Research Article

The Effect of Autologous Platelet Lysate Eye Drops: An In Vivo Confocal Microscopy Study

1Department of Clinical Sciences, Ophthalmology Institute, University of Turin, 10122 Turin, Italy
2Rheumatology Department, AOU Città della Salute e della Scienza di Torino, 10134 Turin, Italy
3Blood Bank, AOU Città della Salute e della Scienza di Torino, 10134 Turin, Italy

Received 13 November 2015; Revised 7 March 2016; Accepted 29 March 2016

Academic Editor: Hong Liang

Copyright © 2016 Antonio M. Fea et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Vitali, S. Bombardieri, R. Jonsson et al., “Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group,” Annals of the Rheumatic Diseases, vol. 61, no. 6, pp. 554–558, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. T. G. Coursey and C. S. de Paiva, “Managing Sjögren's syndrome and non-Sjögren syndrome dry eye with anti-inflammatory therapy,” Clinical Ophthalmology, vol. 8, pp. 1447–1458, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Dogru, M. Nakamura, J. Shimazaki, and K. Tsubota, “Changing trends in the treatment of dry-eye disease,” Expert Opinion on Investigational Drugs, vol. 22, no. 12, pp. 1581–1601, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. T. Subcommittee, “Management and therapy of dry eye disease: report of the Management and Therapy Subcommittee of the International Dry Eye WorkShop (2007),” The Ocular Surface, vol. 5, no. 2, pp. 163–178, 2007. View at Google Scholar
  5. Y. Ohashi, M. Motokura, Y. Kinoshita et al., “Presence of epidermal growth factor in human tears,” Investigative Ophthalmology & Visual Science, vol. 30, no. 8, pp. 1879–1882, 1989. View at Google Scholar
  6. V. Freire, N. Andollo, J. Etxebarria, J. A. Durán, and M.-C. Morales, “In vitro effects of three blood derivatives on human corneal epithelial cells,” Investigative Ophthalmology and Visual Science, vol. 53, no. 9, pp. 5571–5578, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. R. I. Fox, R. Chan, J. B. Michelson, J. B. Belmont, and P. E. Michelson, “Beneficial effect of artificial tears made with autologous serum in patients with keratoconjunctivitis sicca,” Arthritis and Rheumatism, vol. 27, no. 4, pp. 459–461, 1984. View at Publisher · View at Google Scholar · View at Scopus
  8. Q. Pan, A. Angelina, M. Marrone et al., “Autologous serum eye drops for dry eye syndrome,” Cochrane Database of Systematic Reviews, no. 9, Article ID CD009327, 2011. View at Publisher · View at Google Scholar
  9. E. Anitua, F. Muruzabal, A. Tayebba et al., “Autologous serum and plasma rich in growth factors in ophthalmology: preclinical and clinical studies,” Acta Ophthalmologica, vol. 93, no. 8, pp. e605–e614, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. J. L. Alio, J. R. Colecha, S. Pastor, A. Rodriguez, and A. Artola, “Symptomatic dry eye treatment with autologous platelet-rich plasma,” Ophthalmic Research, vol. 39, no. 3, pp. 124–129, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. S. López-Plandolit, M.-C. Morales, V. Freire, A. E. Grau, and J. A. Durán, “Efficacy of plasma rich in growth factors for the treatment of dry eye,” Cornea, vol. 30, no. 12, pp. 1312–1317, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Pezzotta, C. Del Fante, L. Scudeller, M. Cervio, E. R. Antoniazzi, and C. Perotti, “Autologous platelet lysate for treatment of refractory ocular GVHD,” Bone Marrow Transplantation, vol. 47, no. 12, pp. 1558–1563, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. B. R. Masters and M. Böhnke, “Confocal microscopy of the human cornea in vivo,” International Ophthalmology, vol. 23, no. 4–6, pp. 199–206, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. R. F. Guthoff, A. Zhivov, and O. Stachs, “In vivo confocal microscopy, an inner vision of the cornea—a major review,” Clinical and Experimental Ophthalmology, vol. 37, no. 1, pp. 100–117, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. G. Martone, P. Frezzotti, G. M. Tosi et al., “An in vivo confocal microscopy analysis of effects of topical antiglaucoma therapy with preservative on corneal innervation and morphology,” American Journal of Ophthalmology, vol. 147, no. 4, pp. 725.e1–735.e1, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Oliveira-Soto and N. Efron, “Morphology of corneal nerves using confocal microscopy,” Cornea, vol. 20, no. 4, pp. 374–384, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Efron, G. Lee, R. N. Lim et al., “Development and validation of the QUT corneal nerve grading scale,” Cornea, vol. 33, no. 4, pp. 376–381, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. I. S. J. Tuominen, Y. T. Konttinen, M. H. Vesaluoma, J. A. O. Moilanen, M. Helintö, and T. M. T. Tervo, “Corneal innervation and morphology in primary Sjögren's syndrome,” Investigative Ophthalmology and Visual Science, vol. 44, no. 6, pp. 2545–2549, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. E. Villani, D. Galimberti, F. Viola, C. Mapelli, and R. Ratiglia, “The cornea in Sjögren's syndrome: an in vivo confocal study,” Investigative Ophthalmology and Visual Science, vol. 48, no. 5, pp. 2017–2022, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Zhang, J. Chen, L. Luo, Q. Xiao, M. Sun, and Z. Liu, “Altered corneal nerves in aqueous tear deficiency viewed by in vivo confocal microscopy,” Cornea, vol. 24, no. 7, pp. 818–824, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Rao, C. Leveque, and S. C. Pflugfelder, “Corneal nerve regeneration in neurotrophic keratopathy following autologous plasma therapy,” British Journal of Ophthalmology, vol. 94, no. 5, pp. 584–591, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Aggarwal, A. Kheirkhah, B. M. Cavalcanti et al., “Autologous serum tears for treatment of photoallodynia in patients with corneal neuropathy: efficacy and evaluation with in vivo confocal microscopy,” Ocular Surface, vol. 13, no. 3, pp. 250–262, 2015. View at Publisher · View at Google Scholar · View at Scopus
  23. N. Efron, P. B. Morgan, and S. S. Katsara, “Validation of grading scales for contact lens complications,” Ophthalmic and Physiological Optics, vol. 21, no. 1, pp. 17–29, 2001. View at Google Scholar · View at Scopus
  24. “Methodologies to diagnose and monitor dry eye disease: report of the Diagnostic Methodology Subcommittee of the International Dry Eye WorkShop (2007),” The Ocular Surface, vol. 5, no. 2, pp. 108–152, 2007. View at Publisher · View at Google Scholar
  25. P. Aragona, L. Rania, A. M. Roszkowska et al., “Effects of amino acids enriched tears substitutes on the cornea of patients with dysfunctional tear syndrome,” Acta Ophthalmologica, vol. 91, no. 6, pp. e437–e444, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. P. Marsh and S. C. Pflugfelder, “Topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjögren syndrome,” Ophthalmology, vol. 106, no. 4, pp. 811–816, 1999. View at Publisher · View at Google Scholar · View at Scopus
  27. K. Sall, O. D. Stevenson, T. K. Mundorf, and B. L. Reis, “Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease,” Ophthalmology, vol. 107, no. 4, pp. 631–639, 2000. View at Publisher · View at Google Scholar · View at Scopus
  28. D. Stevenson, J. Tauber, and B. L. Reis, “Efficacy and safety of cyclosporin A ophthalmic emulsion in the treatment of moderate-to-servere dry eye disease: a dose-ranging, randomized trial. The cyclosporin A phase 2 study group,” Ophthalmology, vol. 107, no. 5, pp. 967–974, 2000. View at Publisher · View at Google Scholar · View at Scopus
  29. L. D. Barber, S. C. Pflugfelder, J. Tauber, and G. N. Foulks, “Phase III safety evaluation of cyclosporine 0.1% ophthalmic emulsion administered twice daily to dry eye disease patients for up to 3 years,” Ophthalmology, vol. 112, no. 10, pp. 1790–1794, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Wang, Y. Ogawa, M. Dogru et al., “Ocular surface and tear functions after topical cyclosporine treatment in dry eye patients with chronic graft-versus-host disease,” Bone Marrow Transplantation, vol. 41, no. 3, pp. 293–302, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. C. A. Urzua, D. H. Vasquez, A. Huidobro, H. Hernandez, and J. Alfaro, “Randomized double-blind clinical trial of autologous serum versus artificial tears in dry eye syndrome,” Current Eye Research, vol. 37, no. 8, pp. 684–688, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. T. Kojima, R. Ishida, M. Dogru et al., “The effect of autologous serum eyedrops in the treatment of severe dry eye disease: a prospective randomized case-control study,” American Journal of Ophthalmology, vol. 139, no. 2, pp. 242–246, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. A. R. C. Celebi, C. Ulusoy, and G. E. Mirza, “The efficacy of autologous serum eye drops for severe dry eye syndrome: a randomized double-blind crossover study,” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 252, no. 4, pp. 619–626, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Hwang, S.-H. Chung, S. Jeon, S.-K. Kwok, S.-H. Park, and M.-S. Kim, “Comparison of clinical efficacies of autologous serum eye drops in patients with primary and secondary Sjögren syndrome,” Cornea, vol. 33, no. 7, pp. 663–667, 2014. View at Publisher · View at Google Scholar · View at Scopus
  35. J. L. Alio, A. E. Rodriguez, and D. WróbelDudzińska, “Eye platelet-rich plasma in the treatment of ocular surface disorders,” Current Opinion in Ophthalmology, vol. 26, no. 4, pp. 325–332, 2015. View at Publisher · View at Google Scholar · View at Scopus
  36. B. Afzali, G. Lombardi, R. I. Lechler, and G. M. Lord, “The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease,” Clinical and Experimental Immunology, vol. 148, no. 1, pp. 32–46, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. L. Zhou, J. E. Lopes, M. M. W. Chong et al., “TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function,” Nature, vol. 453, no. 7192, pp. 236–240, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. S. Q. Crome, A. Y. Wang, and M. K. Levings, “Translational mini-review series on Th17 cells: function and regulation of human T helper 17 cells in health and disease,” Clinical & Experimental Immunology, vol. 159, no. 2, pp. 109–119, 2010. View at Publisher · View at Google Scholar
  39. T. Habay, S. Majzoub, O. Perrault, C. Rousseau, and P. J. Pisella, “Objective assessment of the functional impact of dry eye severity on the quality of vision by double-pass aberrometry,” Journal Francais d'Ophtalmologie, vol. 37, no. 3, pp. 188–194, 2014. View at Publisher · View at Google Scholar · View at Scopus
  40. H. Lin, W. Li, N. Dong et al., “Changes in corneal epithelial layer inflammatory cells in aqueous tear-deficient dry eye,” Investigative Ophthalmology and Visual Science, vol. 51, no. 1, pp. 122–128, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. F. Machetta, A. M. Fea, A. G. Actis, U. de Sanctis, P. Dalmasso, and F. M. Grignolo, “In vivo confocal microscopic evaluation of corneal langerhans cells in dry eye patients,” Open Ophthalmology Journal, vol. 8, pp. 51–59, 2014. View at Publisher · View at Google Scholar · View at Scopus
  42. A. Alhatem, B. Cavalcanti, and P. Hamrah, “In vivo confocal microscopy in dry eye disease and related conditions,” Seminars in Ophthalmology, vol. 27, no. 5-6, pp. 138–148, 2012. View at Publisher · View at Google Scholar · View at Scopus
  43. S. C. G. Tseng, “Concept and application of limbal stem cells,” Eye, vol. 3, no. 2, pp. 141–157, 1989. View at Publisher · View at Google Scholar · View at Scopus
  44. W. Yu, J. Wang, and J. Yin, “Platelet-rich plasma: a promising product for treatment of peripheral nerve regeneration after nerve injury,” International Journal of Neuroscience, vol. 121, no. 4, pp. 176–180, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. E. Emel, S. S. Ergün, D. Kotan et al., “Effects of insulin-like growth factor-I and platelet-rich plasma on sciatic nerve crush injury in a rat model: laboratory investigation,” Journal of Neurosurgery, vol. 114, no. 2, pp. 522–528, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. T. Y. Farrag, M. Lehar, P. Verhaegen, K. A. Carson, and P. J. Byrne, “Effect of platelet rich plasma and fibrin sealant on facial nerve regeneration in a rat model,” Laryngoscope, vol. 117, no. 1, pp. 157–165, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. J. Javaloy, J. L. Alió, A. E. Rodriguez, A. Vega, and G. Muñoz, “Effect of platelet-rich plasma in nerve regeneration after LASIK,” Journal of Refractive Surgery, vol. 29, no. 3, pp. 213–219, 2013. View at Publisher · View at Google Scholar · View at Scopus
  48. S. Yamagami, P. Hamrah, K. Miyamoto et al., “CCR5 chemokine receptor mediates recruitment of MHC class II-positive Langerhans cells in the mouse corneal epithelium,” Investigative Ophthalmology and Visual Science, vol. 46, no. 4, pp. 1201–1207, 2005. View at Publisher · View at Google Scholar · View at Scopus
  49. L. Shen, S. Barabino, A. W. Taylor, and M. R. Dana, “Effect of the ocular microenvironment in regulating corneal dendritic cell maturation,” Archives of Ophthalmology, vol. 125, no. 7, pp. 908–915, 2007. View at Publisher · View at Google Scholar · View at Scopus
  50. E. Villani, D. Galimberti, F. Viola, C. Mapelli, N. D. Papa, and R. Ratiglia, “Corneal involvement in rheumatoid arthritis: an in vivo confocal study,” Investigative Ophthalmology and Visual Science, vol. 49, no. 2, pp. 560–564, 2008. View at Publisher · View at Google Scholar · View at Scopus
  51. J. S. López-García, I. García-Lozano, L. Rivas, and J. Martínez-Garchitorena, “Use of autologous serum in ophthalmic practice,” Archivos de la Sociedad Espanola de Oftalmologia, vol. 82, no. 1, pp. 9–20, 2007. View at Google Scholar · View at Scopus