Biomolecular Network-Based Synergistic Drug Combination Discovery

Table 3

Important biology network-related databases.

Database	URL	Data type
STRING [39]	http://string-db.org/	Protein-protein interactions
Reactome [40]	http://www.reactome.org/	human biological processes
KEGG [41]	http://www.genome.jp/kegg/	Pathway, disease, drug
BioGRID [42]	https://wiki.thebiogrid.org/	PPI/genetic interaction
STITCH [43]	http://stitch.embl.de/	Chemical-protein interaction
HPRD [44]	http://hprd.org/	Protein-protein interaction (PPI)
DIP [45]	http://dip.doe-mbi.ucla.edu/dip/Main.cgi	PPI
IntAct [46]	http://www.ebi.ac.uk/intact/	Molecular interaction
WikiPathways [47]	http://www.wikipathways.org/index.php/WikiPathways	Biological pathways
TRED [48]	https://cb.utdallas.edu/cgi-bin/TRED/tred.cgi?process=home	TF-gene interaction
InterDom [49]	http://interdom.i2r.a-star.edu.sg/	Domain interaction
SignaLink [50]	http://signalink.org/	Signaling pathways