EF24 Suppresses Invasion and Migration of Hepatocellular Carcinoma Cells In Vitro via Inhibiting the Phosphorylation of Src

Figure 4

EF24 treatment decreases the formation of filopodia on the surface of HCC. HCCLM-3 and HepG2 cells were incubated with or without EF24 for 12 h and then harvested. Electron microscopy was employed to detect the impact of EF24 on the cellular ultrastructure. (a) and (c) showed that HCCLM-3 and HepG2 cells without EF24 treatment have plentiful filopodia (arrow) (×6000). (b) and (d) showed that the filopodia on the surface of HCCLM-3 and HepG2 cells treated with 1 μM EF24 were decreased (×6000).

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