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BioMed Research International
Volume 2016, Article ID 8587164, 8 pages
http://dx.doi.org/10.1155/2016/8587164
Research Article

A Naphthalenic Derivative ND-1 Inhibits Thrombus Formation by Interfering the Binding of Fibrinogen to Integrin αIIbβ3

1School of Life Science & Technology, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
2School of Pharmacy, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China
3Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA
4State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, China

Received 1 September 2016; Revised 28 October 2016; Accepted 10 November 2016

Academic Editor: Jane Hanrahan

Copyright © 2016 Xue Ding et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Fuentes and I. Palomo, “Mechanism of antiplatelet action of hypolipidemic, antidiabetic and antihypertensive drugs by PPAR activation: PPAR agonists: new antiplatelet agents,” Vascular Pharmacology, vol. 62, no. 3, pp. 162–166, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Vilahur and L. Badimon, “Antiplatelet properties of natural products,” Vascular Pharmacology, vol. 59, no. 3-4, pp. 67–75, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. C. T. Wang, B. P. Ji, B. Li et al., “Purification and characterization of a fibrinolytic enzyme of Bacillus subtilis DC33, isolated from Chinese traditional Douchi,” Journal of Industrial Microbiology and Biotechnology, vol. 33, no. 9, pp. 750–758, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. N. Han, Y. Gu, C. Ye, Y. Cao, Z. Liu, and J. Yin, “Antithrombotic activity of fractions and components obtained from raspberry leaves (Rubus chingii),” Food Chemistry, vol. 132, no. 1, pp. 181–185, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. S. R. Steinhubl and D. J. Moliterno, “The role of the platelet in the pathogenesis of atherothrombosis,” American Journal of Cardiovascular Drugs, vol. 5, no. 6, pp. 399–408, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. B. Stein and V. Fuster, “Role of platelet inhibitor therapy in myocardial infarction,” Cardiovascular Drugs and Therapy, vol. 3, no. 6, pp. 797–813, 1989. View at Publisher · View at Google Scholar · View at Scopus
  7. B. S. Coller, L. E. Scudder, J. Beer et al., “Monoclonal antibodies to platelet glycoprotein IIb/IIIa as antithrombotic agents,” Annals of the New York Academy of Sciences, vol. 614, pp. 193–213, 1991. View at Publisher · View at Google Scholar · View at Scopus
  8. D. P. Chew and D. J. Moliterno, “A critical appraisal of platelet glycoprotein IIb/IIIa inhibition,” Journal of the American College of Cardiology, vol. 36, no. 7, pp. 2028–2035, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. Y.-X. Li, Q. Sun, H. Zhang et al., “A novel anti-platelet peptide (Z4A5) potential for glycoprotein IIb/IIIa inhibits platelet aggregation,” Thrombosis Research, vol. 129, no. 5, pp. e217–e222, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Ogawa, A. Sugidachi, H. Naganuma, and F. Asai, “Antiplatelet and antithrombotic effects of orbofiban, a new orally active GPIIb/IIIa antagonist, in guinea pigs,” Thrombosis Research, vol. 97, no. 5, pp. 307–315, 2000. View at Publisher · View at Google Scholar · View at Scopus
  11. O. C. Elcioglu, A. Ozkok, T. S. Akpinar et al., “Severe thrombocytopenia and alveolar hemorrhage represent two types of bleeding tendency during tirofiban treatment: case report and literature review,” International Journal of Hematology, vol. 96, no. 3, pp. 370–375, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. M. W. McClure, S. D. Berkowitz, R. Sparapani et al., “Clinical significance of thrombocytopenia during a non-ST-elevation acute coronary syndrome: the platelet glycoprotein IIb/IIIa in unstable angina: receptor suppression using integrilin therapy (pursuit) trial experience,” Circulation, vol. 99, no. 22, pp. 2892–2900, 1999. View at Publisher · View at Google Scholar · View at Scopus
  13. B. M. Scirica, C. P. Cannon, R. Cooper et al., “Drug-induced thrombocytopenia and thrombosis: evidence from patients receiving an oral glycoprotein IIb/IIIa inhibitor in the orbofiban in patients with unstable coronary syndromes-(OPUS-TIMI 16) trial,” Journal of Thrombosis and Thrombolysis, vol. 22, no. 2, pp. 95–102, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. L. M. Huxtable, M. J. Tafreshi, and A. N. S. Rakkar, “Frequency and management of thrombocytopenia with the glycoprotein IIb/IIIa receptor antagonists,” American Journal of Cardiology, vol. 97, no. 3, pp. 426–429, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Liu, M. E. Fitzgerald, M. C. Berndt, C. W. Jackson, and T. K. Gartner, “Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo,” Blood, vol. 108, no. 8, pp. 2596–2603, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Kim, K.-M. Lim, H.-J. Shin et al., “Inhibitory effects of black soybean on platelet activation mediated through its active component of adenosine,” Thrombosis Research, vol. 131, no. 3, pp. 254–261, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. D. Ma, X. Xu, S. An et al., “A novel family of RGD-containing disintegrins (Tablysin-15) from the salivary gland of the horsefly Tabanus yao targets αIIbβ3 or αVβ3 and inhibits platelet aggregation and angiogenesis,” Thrombosis and Haemostasis, vol. 105, no. 6, pp. 1032–1045, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Tang, Y. Fang, Y. Han et al., “YY-39, a tick anti-thrombosis peptide containing RGD domain,” Peptides, vol. 68, pp. 99–104, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. B. Walkowiak, U. Kralisz, L. Michalec et al., “Comparison of platelet aggregability and P-selectin surface expression on platelets isolated by different methods,” Thrombosis Research, vol. 99, no. 5, pp. 495–502, 2000. View at Publisher · View at Google Scholar · View at Scopus
  20. W. Su, Y. Chen, C. Wang, X. Ding, G. Rwibasira, and Y. Kong, “Human cathelicidin LL-37 inhibits platelet aggregation and thrombosis via Src/PI3K/Akt signaling,” Biochemical and Biophysical Research Communications, vol. 473, no. 1, pp. 283–289, 2016. View at Publisher · View at Google Scholar
  21. X. Fan, P. Shi, J. Dai et al., “Paired immunoglobulin-like receptor B regulates platelet activation,” Blood, vol. 124, no. 15, pp. 2421–2430, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. Z. Xu, X. Chen, H. Zhi et al., “Direct interaction of kindlin-3 with integrin αIIbβ3 in platelets is required for supporting arterial thrombosis in mice,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 34, no. 9, pp. 1961–1967, 2014. View at Publisher · View at Google Scholar
  23. Y. Peng, X. Zeng, Y. Feng, and X. Wang, “Antiplatelet and antithrombotic activity of L-3-n-butylphthalide in rats,” Journal of Cardiovascular Pharmacology, vol. 43, no. 6, pp. 876–881, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. W. Mendes-Silva, M. Assafim, B. Ruta, R. Q. Monteiro, J. A. Guimarães, and R. B. Zingali, “Antithrombotic effect of Glycyrrhizin, a plant-derived thrombin inhibitor,” Thrombosis Research, vol. 112, no. 1-2, pp. 93–98, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. Z. Li, M. K. Delaney, K. A. O'Brien, and X. Du, “Signaling during platelet adhesion and activation,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 30, no. 12, pp. 2341–2349, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. A. B. Chandler, A. D. Earhart, H. E. Speich et al., “Regulation of CD40L (CD154) and CD62P (p-selectin) Surface expression upon GPIIb-IIIa blockade of platelets from stable coronary artery disease patients,” Thrombosis Research, vol. 125, no. 1, pp. 44–52, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. T. J. Stalker, D. K. Newman, P. Ma et al., “Platelet signaling,” in Handbook of Experimental Pharmacology, vol. 21, pp. 59–85, Springer, Berlin, Germany, 2012. View at Google Scholar
  28. B. S. Coller, “αIIbβ3: structure and function,” Journal of Thrombosis and Haemostasis, vol. 13, no. 1, pp. S17–S25, 2015. View at Publisher · View at Google Scholar · View at Scopus
  29. P. A. Merlini, M. Rossi, A. Menozzi et al., “Thrombocytopenia caused by abciximab or tirofiban and its association with clinical outcome in patients undergoing coronary stenting,” Circulation, vol. 109, no. 18, pp. 2203–2206, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. R. Blue, M. Murcia, C. Karan, M. Jiroušková, and B. S. Coller, “Application of high-throughput screening to identify a novel αIIb-specific small-molecule inhibitor of αIIbβ3-mediated platelet interaction with fibrinogen,” Blood, vol. 111, no. 3, pp. 1248–1256, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Li, S. Vootukuri, Y. Shang et al., “RUC-4: a novel αIIBβ3 antagonist for prehospital therapy of myocardial infarction,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 34, no. 10, pp. 2321–2339, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Zhu, W.-S. Choi, J. G. McCoy et al., “Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg2+ binding to the MIDAS,” Science Translational Medicine, vol. 4, no. 125, Article ID 125ra32, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. Aga, K. Baba, S. Tam et al., “UR-3216: a new generation oral platelet GPIIb / IIIa antagonist,” Current Pharmaceutical Design, vol. 10, no. 14, pp. 1597–1601, 2004. View at Publisher · View at Google Scholar