Plasma Neutrophil Gelatinase-Associated Lipocalin as a Predictor of Cardiovascular Events in Patients with Chronic Kidney Disease

Table 3

Predictors of cardiovascular events.

Variable	⁢Nonadjusted		⁢Adjusted
	HR (95% CI)	value	HR (95% CI)	value
Male (yes)	0.99 (0.51–1.95)	1.00
Age (yes)	1.04 (1.01–1.07)	0.01	1.02 (0.99–1.05)	0.24
Diabetes (yes)	1.87 (0.97–3.60)	0.06
Smoking (yes)	0.84 (0.42–1.65)	0.61
Systolic BP (mmHg)	1.02 (0.99–1.04)	0.12
BMI (kg/m^2)	0.95 (0.86–1.05)	0.35
Plasma NGAL (ng/mL)	1.005 (1.003–1.007)	<0.0001	1.004 (1.002–1.006)	<0.0001
Urinary NGAL (μg/gCr)	1.00 (0.999–1.001)	0.71
BNP (pg/mL)	1.005 (1.003–1.006)	<0.0001	1.005 (1.003–1.007)	<0.0001
eGFR (mL/min/1.73 m^2)	0.96 (0.93–0.99)	0.002	0.99 (0.96–1.04)	0.87
Hemoglobin (g/dL)	0.72 (0.60–0.85)	<0.0001	0.94 (0.78–1.14)	0.54
hsCRP (mg/L)	1.78 (1.32–2.35)	<0.0001	1.33 (0.98–1.82)	0.07
UACR (g/gCr)	1.26 (1.09–1.44)	0.001	1.16 (0.97–1.39)	0.09
Triglyceride (mg/dL)	0.99 (0.99–1.00)	0.36
LDL-C (mg/dL)	1.00 (0.99–1.01)	0.40
HDL-C (mg/dL)	0.99 (0.97–1.00)	0.21
LVH of ECG	1.75 (0.53–5.75)	0.36
ST-T change of ECG	1.14 (0.35–3.76)	0.83
EF of UCG	0.94 (0.88–1.00)	0.056
ARB or ACEi (yes)	0.66 (0.33–1.30)	0.23
Statins (yes)	0.96 (0.47–1.95)	0.91

; .
Multivariate model includes all variables with by univariate analysis.
ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; BMI, body mass index; BNP, B-type natriuretic peptide; BP, blood pressure; ECG, electrocardiogram; EF, ejection fraction; eGFR, estimated glomerular filtration rate; HDL-C, high-density lipoprotein-cholesterol; HR, hazard ratio; hsCRP, high-sensitivity C-reactive protein; LDL-C, low-density lipoprotein-cholesterol; LVH, left ventricular hypertrophy; NGAL, neutrophil gelatinase-associated lipocalin; UACR, urinary albumin creatinine ratio; UCG, ultracardiography.